IMMU-04. TARGETING ALTERNATIVE SPLICING VARIANTS TO STIMULATE ANTI-TUMOR IMMUNITY IN A NOVEL SYNGENEIC MOUSE MODEL OF DIFFUSE HEMISPHERIC GLIOMA, H3 G34-MUTANT

Juvenile presentation of HGG has been shown to frequently involve somatic mutations of the H3-3A gene, which encodes a histone H3 variant. To address the paucity of identified TSAs in DHG, we utilized a novel computational platform, Isoform peptides from RNA splicing for Immunotherapy target Screeni...

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Detalles Bibliográficos
Autores principales: Owens, Geoffrey, Pan, Yang, Treger, Janet, Contreras, Erick, Soto, Horacio, Armellini, Amber, Na, Brian, Liau, Linda, Prins, Robert, Xing, Yi, Wang, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Immunology/Immunotherapy - IMMU
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259920/
http://dx.doi.org/10.1093/neuonc/noad073.191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259920/
http://dx.doi.org/10.1093/neuonc/noad073.191

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