HGG-27. THE IMPACT OF MISMATCH REPAIR DEFICIENCY ON GLIOMAS IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS; A REPORT FROM THE IRRDC AND THE GLIOMA TASK FORCE

Mismatch repair deficiency (MMRD) is a pan-cancer mechanism resulting in universal hypermutation. MMRD-gliomas are resistant to chemoradiation but respond to immunotherapy. MMRD can occur somatically or be inherited as part of Lynch Syndrome (LS) or Constitutional Mismatch Repair Deficiency (CMMRD)....

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Detalles Bibliográficos
Autores principales: Negm, Logine, Nobre, Liana, Bennett, Julie, Chung, Jiil, Komosa, Martin, Fernandez, Nick, Ku, Michelle, Johnson, Monique, Bianchi, Vanessa, Aronson, Melyssa, Zhang, Cindy, Stengs, Lucie, Lim-Fat, Mary Jane, Keith, Julia, Tsang, Derek, Gao, Andrew, Munoz, David G, Nguyen, Lananh, Das, Sunit, Levine, Adrian, Das, Anirban, Resnick, Adam, Wheeler, David, Hawkins, Cynthia, Tabori, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: High Grade Glioma/Gliomatosis Cerebri - HGG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259945/
http://dx.doi.org/10.1093/neuonc/noad073.176

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