DIPG-54. UPDATED FINDINGS FROM THE PHASE IB STUDY OF UNESBULIN (PTC596) IN CHILDREN WITH NEWLY-DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND HIGH-GRADE GLIOMA (HGG): A REPORT FROM THE COLLABORATIVE NETWORK FOR NEURO-ONCOLOGY CLINICAL TRIALS (CONNECT)

BMI-1 represents a potential therapeutic target in pediatric HGG given its role in self-renewal and DNA-damage signaling, high expression levels in these tumors, and resultant proliferation blockade, mitotic abnormalities, and radiosensitization when modulated by unesebulin, a microtubule polymeriza...

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Autores principales: Lazow, Margot, Baxter, Patricia, Stanek, Joseph, Rodriguez, Diana, Kumar, Shiva Senthil, Palmer, Joshua, Leach, James, Mikael, Leonie, Thomas, Diana, Fuller, Christine, Boué, Daniel, Pierson, Christopher, Breneman, John, Li, Xiao-Nan, Salloum, Ralph, Ashley, David, de Blank, Peter, Hwang, Eugene, Leary, Sarah, Plant, Ashley, Fisher, Michael, Chi, Susan, Crabtree, Dorothy, Murali, Mythili, Weetall, Marla, Rance, Mark, Maliakal, Pius, Baird, John, D’Silva, Dhiren, O’Keefe, Kylie, Leonard, Jeffrey, Stewart, Clinton, Mardis, Elaine, Fouladi, Maryam, Drissi, Rachid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259955/
http://dx.doi.org/10.1093/neuonc/noad073.101

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