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Molecular basis of ligand-dependent Nurr1-RXRα activation

Small molecule compounds that activate transcription of Nurr1-retinoid X receptor alpha (RXRα) (NR4A2-NR2B1) nuclear receptor heterodimers are implicated in the treatment of neurodegenerative disorders, but function through poorly understood mechanisms. Here, we show that RXRα ligands activate Nurr1...

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Detalles Bibliográficos
Autores principales:	Yu, Xiaoyu, Shang, Jinsai, Kojetin, Douglas J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259986/ https://www.ncbi.nlm.nih.gov/pubmed/37102494 http://dx.doi.org/10.7554/eLife.85039

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