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ATRT-16. THE PI3K INHIBITOR PAXALISIB COMBINES SYNERGISTICALLY WITH THE MEK INHIBITOR MIRDAMETINIB TO TARGET ATYPICAL TERATOID/RHABDOID TUMORS

Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive pediatric brain tumors and the most common malignant brain tumors of infancy. The four-year event-free survival rate is only 37%. There are limited treatment options for patients with relapsed AT/RT, but precision therapies may help improve su...

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Detalles Bibliográficos
Autores principales:	Malebranche, Kristen, Findlay, Tyler, Geethadevi, Anupa, Eberhart, Charles, Raabe, Eric, Rubens, Jeffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Final Category: ATRT/Embryonal/ETMR - ATRT
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260004/ http://dx.doi.org/10.1093/neuonc/noad073.016

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