LGG-02. DRUG-CLASS SPECIFIC GENE-BASED MAPK SENSITIVITY SCORES (MSS) PREDICT SENSITIVITY TO MAPK INHIBITORS AND IDENTIFY IMMUNE INFILTRATION AS PUTATIVE TARGET IN PEDIATRIC LOW-GRADE GLIOMAS

INTRODUCTION: Pediatric low-grade gliomas (pLGG), the most common brain tumors in children, are driven by alterations in the MAPK pathway. Several clinical trials have shown the potential for MAPK inhibitors (MAPKi) treatment in pLGG. However, the range of response is broad, even within entities sha...

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Detalles Bibliográficos
Autores principales: Sigaud, Romain, Albert, Thomas K, Heß, Caroline, Hielscher, Thomas, Winkler, Nadine, Walter, Carolin, Münter, Daniel, Selt, Florian, Usta, Diren, Ecker, Jonas, Brentrup, Angela, Hasselblatt, Martin, Thomas, Christian, Varghese, Julian, Capper, David, Thomale, Ulrich W, Driever, Pablo Hernáiz, Simon, Michèle, Horn, Svea, Herz, Nina Annika, Koch, Arend, Sahm, Felix, Hamelmann, Stefan, Andrade, Augusto Faria, Jabado, Nada, Schouten-van Meeteren, Antoinette Y N, Hoving, Eelco, Brummer, Tilman, van Tilburg, Cornelis M, Pfister, Stefan M, Witt, Olaf, Jones, David T W, Kerl, Kornelius, Milde, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Low Grade Gliomas - LGG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260027/
http://dx.doi.org/10.1093/neuonc/noad073.212

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