TRLS-05. PRELIMINARY RESULTS FROM A PHASE I TRIAL TO EVALUATE INTRAVENTRICULAR DELIVERY OF IL13RΑ2-TARGETING CAR T CELLS AFTER LYMPHODEPLETION IN PEDIATRIC BRAIN TUMORS PATIENTS

Brain tumors are the leading cause of cancer death in children, and outcomes for patients with recurrent or aggressive disease remain poor. We have previously shown that locoregionally-delivered chimeric antigen receptor (CAR) T cells targeting the high-affinity IL13 receptor IL13Rα2 are safe and we...

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Detalles Bibliográficos
Autores principales: Davidson, Tom, Oill, Angela, Wu, Melody, Egelston, Colt, Natri, Heini, Sepulveda, Sean, Hibbard, Jonathan, Wagner, Jamie, Nisis, Monica, Kilpatrick, Julie, Stiller, Tracey, Georges, Joseph, Munoz, Margarita, Oliver-Cervantes, Cheryl, Shepphird, Jennifer, Ressler, Julie, D’Apuzzo, Massimo, Aftabizadeh, Maryam, Blanchard, M Suzette, Badie, Behnam, Brown, Christine, Banovich, Nicholas, Wang, Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Translational Therapeutics/Clinical Trials - TRLS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260042/
http://dx.doi.org/10.1093/neuonc/noad073.308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260042/
http://dx.doi.org/10.1093/neuonc/noad073.308

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