HGG-13. ONCOGENIC STAT3 AND SHP2 ACTIVATION IN ROS1-FUSION DRIVEN INFANT-TYPE HEMISPHERIC GLIOMAS

Genomic analyzes identified a subgroup of gliomas – infant-type hemispheric gliomas – that are driven by oncogenic fusions of, amongst others, ROS1 receptor tyrosine kinase with a variety of fusion partners. These fusions result in ligand independent constitutively active oncogenic kinases. In the p...

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Detalles Bibliográficos
Autores principales: Postlmayr, Andreas, De Micheli, Andrea, Hofmann, Nina, Zuckermann, Marc, Stücklin, Ana Guerreiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: High Grade Glioma/Gliomatosis Cerebri - HGG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260073/
http://dx.doi.org/10.1093/neuonc/noad073.162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260073/
http://dx.doi.org/10.1093/neuonc/noad073.162

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