XRT-03. EFFICACY OF RE-IRRADIATION FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS

OBJECTIVE: To analyze the efficacy and prognosticators of pediatric diffuse intrinsic pontine glioma (DPC) treated with re-irradiation. METHODS: The clinical data and prognostic information of DIPG children younger than 18 years old who received re-irradiation in the Department of Oncology of Guangdong Sanjiu Brain Hospital from May 1, 2021, to November 1, 2022, were collected. The overall survival (OS) was calculated, and univariate analysis was performed to analyze the effect of tumor volume change and rate of change on survival. RESULTS: Fifteen patients met the inclusion criteria. The median interval between the first and second radiotherapy was 8.8 months. The median survival after re-irradiation was 3.9 months, and the median overall survival was 16.9 months. Severe complications such as fatal radiation brain necrosis was observed after re-irradiation. CONCLUSIONS: Re-irradiation is still the primary treatment for pediatric diffuse intrinsic pontine glioma, prolonging their survival.