HGG-16. COMPARATIVE ANALYSIS OF AUTOPHAGY IN DRUG RESPONSES AND AGGRESSIVE BEHAVIOR OF ADULT VERSUS PEDIATRIC GLIOMA CELL LINES

Central nervous system tumors are the most common solid cancer and a leading cause of cancer-related deaths in children. Glioma is the most challenging pediatric CNS tumor with therapy resistance and poor prognosis in pediatric patients. Although histopathological analyses revealed similarities with...

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Autores principales: Yenidogan, Irem, Peker, Nesibe, Deveci, Gamze, Aygun, Bera, Kirmizi, Dondu, Al, Nathalie, Asarcikli, Fikret, Oflaz Sozmen, Banu, Akyoldas, Goktug, Kulac, Ibrahim, Solaroglu, Ihsan, Gozuacik, Devrim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: High Grade Glioma/Gliomatosis Cerebri - HGG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260088/
http://dx.doi.org/10.1093/neuonc/noad073.165
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author Yenidogan, Irem
Peker, Nesibe
Deveci, Gamze
Aygun, Bera
Kirmizi, Dondu
Al, Nathalie
Asarcikli, Fikret
Oflaz Sozmen, Banu
Akyoldas, Goktug
Kulac, Ibrahim
Solaroglu, Ihsan
Gozuacik, Devrim
author_facet Yenidogan, Irem
Peker, Nesibe
Deveci, Gamze
Aygun, Bera
Kirmizi, Dondu
Al, Nathalie
Asarcikli, Fikret
Oflaz Sozmen, Banu
Akyoldas, Goktug
Kulac, Ibrahim
Solaroglu, Ihsan
Gozuacik, Devrim
author_sort Yenidogan, Irem
collection PubMed
description Central nervous system tumors are the most common solid cancer and a leading cause of cancer-related deaths in children. Glioma is the most challenging pediatric CNS tumor with therapy resistance and poor prognosis in pediatric patients. Although histopathological analyses revealed similarities with adult brain glioma, emerging evidence suggests that the deregulated molecular pathways in pediatric glioma (p-GM) are different from that of adults. Autophagy, a cellular clearance system and a drug resistance mechanism, has been implicated in glioma progression, invasion, and relapse, yet its role in pediatric patients is not well documented. In this study, we compared the autophagic capacity of adult versus p-GM cell lines and evaluated the effect of autophagy manipulation on drug responses. In addition, migration, extracellular matrix invasion ability, and the metabolism of pediatric and adult gliomas were compared and the contribution of autophagy to the aggressive phenotype was evaluated.
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spelling pubmed-102600882023-06-13 HGG-16. COMPARATIVE ANALYSIS OF AUTOPHAGY IN DRUG RESPONSES AND AGGRESSIVE BEHAVIOR OF ADULT VERSUS PEDIATRIC GLIOMA CELL LINES Yenidogan, Irem Peker, Nesibe Deveci, Gamze Aygun, Bera Kirmizi, Dondu Al, Nathalie Asarcikli, Fikret Oflaz Sozmen, Banu Akyoldas, Goktug Kulac, Ibrahim Solaroglu, Ihsan Gozuacik, Devrim Neuro Oncol Final Category: High Grade Glioma/Gliomatosis Cerebri - HGG Central nervous system tumors are the most common solid cancer and a leading cause of cancer-related deaths in children. Glioma is the most challenging pediatric CNS tumor with therapy resistance and poor prognosis in pediatric patients. Although histopathological analyses revealed similarities with adult brain glioma, emerging evidence suggests that the deregulated molecular pathways in pediatric glioma (p-GM) are different from that of adults. Autophagy, a cellular clearance system and a drug resistance mechanism, has been implicated in glioma progression, invasion, and relapse, yet its role in pediatric patients is not well documented. In this study, we compared the autophagic capacity of adult versus p-GM cell lines and evaluated the effect of autophagy manipulation on drug responses. In addition, migration, extracellular matrix invasion ability, and the metabolism of pediatric and adult gliomas were compared and the contribution of autophagy to the aggressive phenotype was evaluated. Oxford University Press 2023-06-12 /pmc/articles/PMC10260088/ http://dx.doi.org/10.1093/neuonc/noad073.165 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Final Category: High Grade Glioma/Gliomatosis Cerebri - HGG
Yenidogan, Irem
Peker, Nesibe
Deveci, Gamze
Aygun, Bera
Kirmizi, Dondu
Al, Nathalie
Asarcikli, Fikret
Oflaz Sozmen, Banu
Akyoldas, Goktug
Kulac, Ibrahim
Solaroglu, Ihsan
Gozuacik, Devrim
HGG-16. COMPARATIVE ANALYSIS OF AUTOPHAGY IN DRUG RESPONSES AND AGGRESSIVE BEHAVIOR OF ADULT VERSUS PEDIATRIC GLIOMA CELL LINES
title HGG-16. COMPARATIVE ANALYSIS OF AUTOPHAGY IN DRUG RESPONSES AND AGGRESSIVE BEHAVIOR OF ADULT VERSUS PEDIATRIC GLIOMA CELL LINES
title_full HGG-16. COMPARATIVE ANALYSIS OF AUTOPHAGY IN DRUG RESPONSES AND AGGRESSIVE BEHAVIOR OF ADULT VERSUS PEDIATRIC GLIOMA CELL LINES
title_fullStr HGG-16. COMPARATIVE ANALYSIS OF AUTOPHAGY IN DRUG RESPONSES AND AGGRESSIVE BEHAVIOR OF ADULT VERSUS PEDIATRIC GLIOMA CELL LINES
title_full_unstemmed HGG-16. COMPARATIVE ANALYSIS OF AUTOPHAGY IN DRUG RESPONSES AND AGGRESSIVE BEHAVIOR OF ADULT VERSUS PEDIATRIC GLIOMA CELL LINES
title_short HGG-16. COMPARATIVE ANALYSIS OF AUTOPHAGY IN DRUG RESPONSES AND AGGRESSIVE BEHAVIOR OF ADULT VERSUS PEDIATRIC GLIOMA CELL LINES
title_sort hgg-16. comparative analysis of autophagy in drug responses and aggressive behavior of adult versus pediatric glioma cell lines
topic Final Category: High Grade Glioma/Gliomatosis Cerebri - HGG
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260088/
http://dx.doi.org/10.1093/neuonc/noad073.165
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