HGG-19. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG ADULT HIGH-GRADE GLIOMA PATIENTS WITH H3K27M OR PDGFRA GENOMIC ALTERATIONS

PDGFRA is commonly altered in pediatric and young adult high-grade gliomas (pHGGs) including histone 3 lysine 27-mutated diffuse midline gliomas (H3K27M DMG), a fatal disease with no current options for cure. We performed comprehensive genomic and transcriptomic analyses of n=259 pediatric high-grad...

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Autores principales: Trissal, Maria, Mayr, Lisa, Schwark, Kallen, LaBelle, Jenna, Kong, Seongbae, Furtner, Julia, Weiler-Wichtl, Liesa, Supko, Jeffrey, Rozowsky, Jacob, Hack, Olivia, Groves, Andrew, Marques, Joana, Leiss, Ulrike, Rosenmayr, Verena, Dubois, Frank, Greenwald, Noah F, Madlener, Sibylle, Guntner, Armin Sebastian, Pálová, Hana, Stepien, Natalia, Lötsch-Gojo, Daniela, Dorfer, Christian, Dieckmann, Karen, Peyrl, Andreas, Azizi, Amadeo A, Baumgartner, Alicia, Slabý, Ondřej, Pokorná, Petra, Bandopadhayay, Pratiti, Rameen_Beroukhim@dfci.harvard.edu Beroukhim, Rameen Beroukhim, Ligon, Keith L, Kramm, Christof M, Bronsema, Annika, Bailey, Simon, Stucklin, Ana Guerreiro, Mueller, Sabine Mueller, Jones, David T W, Jäger, Natalie, Mullauer, Leonhard, Haberler, Christine, Kumar-Sinha, Chandan, Chinnaiyan, Arul, Mody, Rajen, Sterba.Jaroslav@fnbrno.cz Štěrba, Jaroslav Štěrba, Skrypek, Mary, Martinez, Nina, Bowers, Daniel C, Koschmann, Carl Koschmann, Gojo, Johannes, Filbin, Mariella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: High Grade Glioma/Gliomatosis Cerebri - HGG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260101/
http://dx.doi.org/10.1093/neuonc/noad073.168

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