MDB-12. TRANS-SPECIES ANALYSIS OF REPLICATION-REPAIR DEFICIENT (RRD) MEDULLOBLASTOMA AND RESPONSE TO IMMUNE-CHECKPOINT INHIBITION: AN IRRDC REPORT

BACKGROUND: Replication-repair deficiency (RRD) stemming from mismatch repair and polymerase-proofreading gene defects (MMRD/PPD) lead to hypermutant childhood cancers, most frequently brain tumors. While medulloblastoma is reported, the clinical, genomic and immune landscape remains unknown. METHOD...

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Detalles Bibliográficos
Autores principales: Das, Anirban, Fernandez, Nicholas R, Levine, Adrian, Smith, Kyle, Wang, Evan, Galati, Melissa, Aamir, Zoya, Chung, Jill, Negm, Logine, Crump, Owen, Trinh, Quang, Nunes, Nuno M, Bianchi, Vanessa, Stengs, Lucie, Edwards, Melissa, Stein, Lincoln, Bouffet, Eric, Taylor, Michael, Northcott, Paul, Ramaswamy, Vijay, Hawkins, Cynthia, Tabori, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Medulloblastomas - MDB
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260105/
http://dx.doi.org/10.1093/neuonc/noad073.245

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