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LGG-03. EXPLORING THE SIGNALING NETWORK INVOLVED IN MAPK PATHWAY INHIBITION BY THE MEK INHIBITOR TRAMETINIB IN BRAF-FUSION-DRIVEN PEDIATRIC PILOCYTIC ASTROCYTOMA

INTRODUCTION: Pilocytic astrocytomas (PA) are the most common pediatric brain tumors. They are characterized by MAPK pathway alterations, leading to its constitutive activation and modulating the balance between proliferation and oncogene-induced senescence (OIS) sustained by senescence-associated s...

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Detalles Bibliográficos
Autores principales:	Sigaud, Romain, Stefanski, Anja, Selt, Florian, Hielscher, Thomas, Usta, Diren, Kocher, Daniela, Picard, Daniel, Büdenbender, Isabel, Remke, Marc, Pfister, Stefan M, Jones, David T W, Brummer, Tilman, Witt, Olaf, Milde, Till
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Final Category: Low Grade Gliomas - LGG
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260117/ http://dx.doi.org/10.1093/neuonc/noad073.213

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