DIPG-36. H3K27M HISTONE MUTANT GLIOMAS ARE SENSITIVE TO METHIONINE LOSS AND MAT2A INHIBITION THROUGH A NOVEL FEEDBACK MECHANISM BETWEEN AMD1 AND METTL16

Diffuse Midline gliomas (DMGs) are grade IV tumors by the World Health Organization. They are inoperable and resistant to chemo/radiotherapies resulting in a median survival of 8-11 months and a 5-year survival of <2%. DMG is an epigenetic disease characterized by mutations on histone H3.3 K27M r...

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Detalles Bibliográficos
Autores principales: Chilukuri, Akanksha, Halbert, Matthew, Golbourn, Brian, Varadharajan, Srinidhi, Krug, Brian, Mbah, Nneka, Casillo, Stephanie, Gatesman, Taylor, Cruz, Andrea, Zapotocky, Michael, Hu, Baoli, Kohanbash, Gary, Bertrand, Kelsey, Kleinman, Claudia, Lyssiotis, Costas, Jabado, Nada, Pollack, Ian, Mack, Stephen, Agnihotri, Sameer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260120/
http://dx.doi.org/10.1093/neuonc/noad073.083

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