MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA

Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor with Group 3 MB exhibiting the worst prognosis. Overexpression/amplification of OTX2 is a molecular hallmark of Group 3 MB and is primarily known to control tumor growth through regulation of cell cycle. Here, we utilize...

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Detalles Bibliográficos
Autores principales: Saulnier, Olivier, Zagozewski, Jamie, Liang, Lisa, Hendrikse, Liam D, Gordon, Victor, Aldinger, Kimberly A, Haldipur, Parthiv, Borlase, Stephanie, Coudiere-Morrison, Ludivine, Layug, Paul, Cai, Ting, Porter, Christopher J, Richard, Stephane, Doble, Brad W, Millen, Kathleen J, Taylor, Michael D, Werbowetski-Ogilvie, Tamra E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Medulloblastomas - MDB
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260131/
http://dx.doi.org/10.1093/neuonc/noad073.254

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