DIPG-30. HIF2 OVEREXPRESSION DICTATES AGGRESSIVENESS ADDITIONALLY TO TP53 MUTATIONS IN H3.3K27M PEDIATRIC HIGH-GRADE GLIOMAS THROUGH RAS-MAPK AND WNT/BCATENIN PATHWAYS

Diffuse midline (DMG) and brainstem (DIPG) high-grade gliomas (HGG) bearing H3.3K27M driver mutation are aggressive and uncurable brain tumors. We evidenced by the past HIF-2a and its transcriptional gene, EPAS1, as a marker of resistance when targeting mTor/HIF-1a pathway. To understand HIF-2α pote...

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Detalles Bibliográficos
Autores principales: Fuchs, Quentin, Legras, Stephanie, Lhermitte, Benoit, Vauchelles, Romain, Cosset, Erika, Gorka, Lucas, Outilaft, Hassiba, Namer, Izzie Jacques, Guerin, Eric, Mura, Carole, Burckel, Hélène, Noel, Georges, Hibaoui, Youssef, Feki, Anis, Chammas, Agathe, Wolf, Thibaut, Coca, Andres Hugo, Foppolo, Sophie, Dontenwill, Monique, Entz-Werlé, Natacha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260148/
http://dx.doi.org/10.1093/neuonc/noad073.077

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