DIPG-19. BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA

Epigenetic dysregulation resulting in stalled development plays a crucial role in pediatric cancer tumorigenesis. Diffuse midline gliomas (DMG) are universally fatal pediatric brain cancers refractory to standard of care treatment modalities. These malignancies are driven by heterozygous mutations i...

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Autores principales: Panditharatna, Eshini, Marques, Joana G, Wang, Tingjian, Trissal, Maria, Liu, Ilon, Jiang, Li, Beck, Alexander, Groves, Andrew, Dharia, Neekesh, Hoffman, Samantha, Kugener, Guillaume, Shaw, McKenzie, Hack, Olivia, Dempster, Joshua, Lareau, Caleb, Quezada, Michael, Stanton, Ann-Catherine, Wyatt, Meghan, Kalani, Zohra, Goodale, Amy, Vazquez, Francisca, Piccioni, Federica, Doench, John, Root, David, Anastas, Jamie, Jones, Kristen, Conway, Amy, Stopka, Sylwia, Regan, Michael, Liang, Yu, Seo, Hyuk-Soo, Song, Kijun, Bashyal, Puspalata, Mathewson, Nathan, Dhe-Paganon, Sirano, Suvà, Mario L, Carcaboso, Angel M, Lavarino, Cinzia, Mora, Jaume, Nguyen, Quang-De, Ligon, Keith L, Shi, Yang, Agnihotri, Sameer, Agar, Nathalie Y R, Stegmaier, Kimberly, Stiles, Charles D, Monje, Michelle, Golub, Todd R, Qi, Jun, Filbin, Mariella G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260176/
http://dx.doi.org/10.1093/neuonc/noad073.066

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