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DIPG-53. LSD1 DEGRADATION SYNERGIZES WITH HDAC INHIBITION IN PEDIATRIC H3K27M DIFFUSE MIDLINE GLIOMA

H3K27M-mutated diffuse midline glioma (H3K27M DMG) is an aggressive, lethal pediatric brain tumor which resists conventional cancer treatments. To identify new therapeutic targets, our lab executed a focused CRISPR negative selection screen in patient-derived H3K27M cell lines after treatment with t...

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Detalles Bibliográficos
Autores principales:	Haase, Rebecca, Groves, Andrew, Mire, Hafsa, Qi, Jun, Filbin, Mariella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260181/ http://dx.doi.org/10.1093/neuonc/noad073.100

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