DIPG-46. TARGETING THE METABOLIC ERK5-PFKFB3 AXIS IN PEDIATRIC DIFFUSE MIDLINE GLIOMA

Diffuse midline glioma is an aggressive brain tumor with a median age at diagnosis of 6.3 years and 5-year survival rate of 2.2%.The defining histone mutation H3K27M precludes docking of a protein responsible for epigenetic modification resulting in erroneously accessible chromatin and subsequent tr...

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Detalles Bibliográficos
Autores principales: Casillo, Stephanie, Gatesman, Taylor, Chilukuri, Akanksha, Jane, Esther, Premkumar, Daniel, Barber, Callie, Halbert, Matthew, Cruz, Andrea, Mullett, Steven, Michel, Joshua, Chang, Yue-Fang, MichaelRaj, Antony, Lieberman, Frank, Felker, James, Shiva, Sruti, Abdullah, Kalil, Zinn, Pascal, Friedlander, Robert, Abel, Taylor, Venneti, Sriram, Mack, Stephen, Wendell, Stacy, Pollack, Ian, Agnihotri, Sameer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260195/
http://dx.doi.org/10.1093/neuonc/noad073.093

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