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The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase
To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the number of designated resistance genes in the wheat gene pool(1). Isolating these genes facilitates their fast-tracking in breeding programs and incorporat...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260397/ https://www.ncbi.nlm.nih.gov/pubmed/37217714 http://dx.doi.org/10.1038/s41588-023-01402-1 |
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| author | Yu, Guotai Matny, Oadi Gourdoupis, Spyridon Rayapuram, Naganand Aljedaani, Fatimah R. Wang, Yan L. Nürnberger, Thorsten Johnson, Ryan Crean, Emma E. Saur, Isabel M.-L. Gardener, Catherine Yue, Yajuan Kangara, Ngonidzashe Steuernagel, Burkhard Hayta, Sadiye Smedley, Mark Harwood, Wendy Patpour, Mehran Wu, Shuangye Poland, Jesse Jones, Jonathan D. G. Reuber, T. Lynne Ronen, Moshe Sharon, Amir Rouse, Matthew N. Xu, Steven Holušová, Kateřina Bartoš, Jan Molnár, István Karafiátová, Miroslava Hirt, Heribert Blilou, Ikram Jaremko, Łukasz Doležel, Jaroslav Steffenson, Brian J. Wulff, Brande B. H. |
| author_facet | Yu, Guotai Matny, Oadi Gourdoupis, Spyridon Rayapuram, Naganand Aljedaani, Fatimah R. Wang, Yan L. Nürnberger, Thorsten Johnson, Ryan Crean, Emma E. Saur, Isabel M.-L. Gardener, Catherine Yue, Yajuan Kangara, Ngonidzashe Steuernagel, Burkhard Hayta, Sadiye Smedley, Mark Harwood, Wendy Patpour, Mehran Wu, Shuangye Poland, Jesse Jones, Jonathan D. G. Reuber, T. Lynne Ronen, Moshe Sharon, Amir Rouse, Matthew N. Xu, Steven Holušová, Kateřina Bartoš, Jan Molnár, István Karafiátová, Miroslava Hirt, Heribert Blilou, Ikram Jaremko, Łukasz Doležel, Jaroslav Steffenson, Brian J. Wulff, Brande B. H. |
| author_sort | Yu, Guotai |
| collection | PubMed |
| description | To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the number of designated resistance genes in the wheat gene pool(1). Isolating these genes facilitates their fast-tracking in breeding programs and incorporation into polygene stacks for more durable resistance. We cloned the stem rust resistance gene Sr43, which was crossed into bread wheat from the wild grass Thinopyrum elongatum(2,3). Sr43 encodes an active protein kinase fused to two domains of unknown function. The gene, which is unique to the Triticeae, appears to have arisen through a gene fusion event 6.7 to 11.6 million years ago. Transgenic expression of Sr43 in wheat conferred high levels of resistance to a wide range of isolates of the pathogen causing stem rust, highlighting the potential value of Sr43 in resistance breeding and engineering. |
| format | Online Article Text |
| id | pubmed-10260397 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-102603972023-06-15 The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase Yu, Guotai Matny, Oadi Gourdoupis, Spyridon Rayapuram, Naganand Aljedaani, Fatimah R. Wang, Yan L. Nürnberger, Thorsten Johnson, Ryan Crean, Emma E. Saur, Isabel M.-L. Gardener, Catherine Yue, Yajuan Kangara, Ngonidzashe Steuernagel, Burkhard Hayta, Sadiye Smedley, Mark Harwood, Wendy Patpour, Mehran Wu, Shuangye Poland, Jesse Jones, Jonathan D. G. Reuber, T. Lynne Ronen, Moshe Sharon, Amir Rouse, Matthew N. Xu, Steven Holušová, Kateřina Bartoš, Jan Molnár, István Karafiátová, Miroslava Hirt, Heribert Blilou, Ikram Jaremko, Łukasz Doležel, Jaroslav Steffenson, Brian J. Wulff, Brande B. H. Nat Genet Letter To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the number of designated resistance genes in the wheat gene pool(1). Isolating these genes facilitates their fast-tracking in breeding programs and incorporation into polygene stacks for more durable resistance. We cloned the stem rust resistance gene Sr43, which was crossed into bread wheat from the wild grass Thinopyrum elongatum(2,3). Sr43 encodes an active protein kinase fused to two domains of unknown function. The gene, which is unique to the Triticeae, appears to have arisen through a gene fusion event 6.7 to 11.6 million years ago. Transgenic expression of Sr43 in wheat conferred high levels of resistance to a wide range of isolates of the pathogen causing stem rust, highlighting the potential value of Sr43 in resistance breeding and engineering. Nature Publishing Group US 2023-05-22 2023 /pmc/articles/PMC10260397/ /pubmed/37217714 http://dx.doi.org/10.1038/s41588-023-01402-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Letter Yu, Guotai Matny, Oadi Gourdoupis, Spyridon Rayapuram, Naganand Aljedaani, Fatimah R. Wang, Yan L. Nürnberger, Thorsten Johnson, Ryan Crean, Emma E. Saur, Isabel M.-L. Gardener, Catherine Yue, Yajuan Kangara, Ngonidzashe Steuernagel, Burkhard Hayta, Sadiye Smedley, Mark Harwood, Wendy Patpour, Mehran Wu, Shuangye Poland, Jesse Jones, Jonathan D. G. Reuber, T. Lynne Ronen, Moshe Sharon, Amir Rouse, Matthew N. Xu, Steven Holušová, Kateřina Bartoš, Jan Molnár, István Karafiátová, Miroslava Hirt, Heribert Blilou, Ikram Jaremko, Łukasz Doležel, Jaroslav Steffenson, Brian J. Wulff, Brande B. H. The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase |
| title | The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase |
| title_full | The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase |
| title_fullStr | The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase |
| title_full_unstemmed | The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase |
| title_short | The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase |
| title_sort | wheat stem rust resistance gene sr43 encodes an unusual protein kinase |
| topic | Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260397/ https://www.ncbi.nlm.nih.gov/pubmed/37217714 http://dx.doi.org/10.1038/s41588-023-01402-1 |
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