Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

Aldosterone-producing adenomas (APAs) are the commonest curable cause of hypertension. Most have gain-of-function somatic mutations of ion channels or transporters. Herein we report the discovery, replication and phenotype of mutations in the neuronal cell adhesion gene CADM1. Independent whole exom...

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Detalles Bibliográficos
Autores principales: Wu, Xilin, Azizan, Elena A. B., Goodchild, Emily, Garg, Sumedha, Hagiyama, Man, Cabrera, Claudia P., Fernandes-Rosa, Fabio L., Boulkroun, Sheerazed, Kuan, Jyn Ling, Tiang, Zenia, David, Alessia, Murakami, Masanori, Mein, Charles A., Wozniak, Eva, Zhao, Wanfeng, Marker, Alison, Buss, Folma, Saleeb, Rebecca S., Salsbury, Jackie, Tezuka, Yuta, Satoh, Fumitoshi, Oki, Kenji, Udager, Aaron M., Cohen, Debbie L., Wachtel, Heather, King, Peter J., Drake, William M., Gurnell, Mark, Ceral, Jiri, Ryska, Ales, Mustangin, Muaatamarulain, Wong, Yin Ping, Tan, Geok Chin, Solar, Miroslav, Reincke, Martin, Rainey, William E., Foo, Roger S., Takaoka, Yutaka, Murray, Sandra A., Zennaro, Maria-Christina, Beuschlein, Felix, Ito, Akihiko, Brown, Morris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260400/
https://www.ncbi.nlm.nih.gov/pubmed/37291193
http://dx.doi.org/10.1038/s41588-023-01403-0

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