Cargando…

Long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal NK/T-cell lymphoma of the small intestine: a retrospective case study

BACKGROUND: Extranodal natural killer/T-cell lymphoma, nasal type (ENKL) of the small intestine, is a disease with extremely poor prognosis. We describe treatment in a case which is novel in that it demonstrated long-term survival. CASE PRESENTATION: A 68-year-old man was admitted to the emergency d...

Descripción completa

Detalles Bibliográficos
Autores principales: Funaki, Hiroshi, Nojima, Naomi, Takikawa, Yutaka, Komori, Kazutoshi, Hasegawa, Hajime, Sakai, Tomoyuki, Yamada, Sohsuke, Masaki, Yasufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260716/
https://www.ncbi.nlm.nih.gov/pubmed/37306807
http://dx.doi.org/10.1186/s40792-023-01688-7
_version_ 1785057862208192512
author Funaki, Hiroshi
Nojima, Naomi
Takikawa, Yutaka
Komori, Kazutoshi
Hasegawa, Hajime
Sakai, Tomoyuki
Yamada, Sohsuke
Masaki, Yasufumi
author_facet Funaki, Hiroshi
Nojima, Naomi
Takikawa, Yutaka
Komori, Kazutoshi
Hasegawa, Hajime
Sakai, Tomoyuki
Yamada, Sohsuke
Masaki, Yasufumi
author_sort Funaki, Hiroshi
collection PubMed
description BACKGROUND: Extranodal natural killer/T-cell lymphoma, nasal type (ENKL) of the small intestine, is a disease with extremely poor prognosis. We describe treatment in a case which is novel in that it demonstrated long-term survival. CASE PRESENTATION: A 68-year-old man was admitted to the emergency department of our hospital with the complaint of severe umbilical pain with tenderness and muscular defense. An abdominal computed tomography scan revealed a thick-wall mass on the small intestine and intra-abdominal free air. He was suspected of perforation of a small intestinal tumor and underwent emergency surgery. The surgery revealed a perforated tumor ulcer, and ENKL was diagnosed from the postoperative pathological findings. The patient’s postoperative course was uneventful. He was further treated with adjuvant chemotherapy by hematologist comprising six courses of dexamethasone, etoposide, ifosfamide, and carboplatin. The patient demonstrated long-term survival and was in remission at the time of writing, four years and five months after surgery. CONCLUSIONS: We report a rare case of long-term survival of perforated ENKL of the small intestine achieved by surgery and adjuvant chemotherapy with dexamethasone, etoposide, ifosfamide, and carboplatin. It is essential to consult with a hematologist to determine the most appropriate chemotherapy such as DeVIC if one encounters rare postoperative pathological findings of ENKL. To elucidate the pathophysiology of this disease and to prolong survival of affected patients, accumulation of cases of long-term survival and examination of associated characteristics is necessary.
format Online
Article
Text
id pubmed-10260716
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-102607162023-06-15 Long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal NK/T-cell lymphoma of the small intestine: a retrospective case study Funaki, Hiroshi Nojima, Naomi Takikawa, Yutaka Komori, Kazutoshi Hasegawa, Hajime Sakai, Tomoyuki Yamada, Sohsuke Masaki, Yasufumi Surg Case Rep Case Report BACKGROUND: Extranodal natural killer/T-cell lymphoma, nasal type (ENKL) of the small intestine, is a disease with extremely poor prognosis. We describe treatment in a case which is novel in that it demonstrated long-term survival. CASE PRESENTATION: A 68-year-old man was admitted to the emergency department of our hospital with the complaint of severe umbilical pain with tenderness and muscular defense. An abdominal computed tomography scan revealed a thick-wall mass on the small intestine and intra-abdominal free air. He was suspected of perforation of a small intestinal tumor and underwent emergency surgery. The surgery revealed a perforated tumor ulcer, and ENKL was diagnosed from the postoperative pathological findings. The patient’s postoperative course was uneventful. He was further treated with adjuvant chemotherapy by hematologist comprising six courses of dexamethasone, etoposide, ifosfamide, and carboplatin. The patient demonstrated long-term survival and was in remission at the time of writing, four years and five months after surgery. CONCLUSIONS: We report a rare case of long-term survival of perforated ENKL of the small intestine achieved by surgery and adjuvant chemotherapy with dexamethasone, etoposide, ifosfamide, and carboplatin. It is essential to consult with a hematologist to determine the most appropriate chemotherapy such as DeVIC if one encounters rare postoperative pathological findings of ENKL. To elucidate the pathophysiology of this disease and to prolong survival of affected patients, accumulation of cases of long-term survival and examination of associated characteristics is necessary. Springer Berlin Heidelberg 2023-06-12 /pmc/articles/PMC10260716/ /pubmed/37306807 http://dx.doi.org/10.1186/s40792-023-01688-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Funaki, Hiroshi
Nojima, Naomi
Takikawa, Yutaka
Komori, Kazutoshi
Hasegawa, Hajime
Sakai, Tomoyuki
Yamada, Sohsuke
Masaki, Yasufumi
Long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal NK/T-cell lymphoma of the small intestine: a retrospective case study
title Long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal NK/T-cell lymphoma of the small intestine: a retrospective case study
title_full Long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal NK/T-cell lymphoma of the small intestine: a retrospective case study
title_fullStr Long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal NK/T-cell lymphoma of the small intestine: a retrospective case study
title_full_unstemmed Long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal NK/T-cell lymphoma of the small intestine: a retrospective case study
title_short Long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal NK/T-cell lymphoma of the small intestine: a retrospective case study
title_sort long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal nk/t-cell lymphoma of the small intestine: a retrospective case study
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260716/
https://www.ncbi.nlm.nih.gov/pubmed/37306807
http://dx.doi.org/10.1186/s40792-023-01688-7
work_keys_str_mv AT funakihiroshi longtermsurvivalbysurgeryandadjuvantchemotherapyinapatientwithperforatedextranodalnktcelllymphomaofthesmallintestinearetrospectivecasestudy
AT nojimanaomi longtermsurvivalbysurgeryandadjuvantchemotherapyinapatientwithperforatedextranodalnktcelllymphomaofthesmallintestinearetrospectivecasestudy
AT takikawayutaka longtermsurvivalbysurgeryandadjuvantchemotherapyinapatientwithperforatedextranodalnktcelllymphomaofthesmallintestinearetrospectivecasestudy
AT komorikazutoshi longtermsurvivalbysurgeryandadjuvantchemotherapyinapatientwithperforatedextranodalnktcelllymphomaofthesmallintestinearetrospectivecasestudy
AT hasegawahajime longtermsurvivalbysurgeryandadjuvantchemotherapyinapatientwithperforatedextranodalnktcelllymphomaofthesmallintestinearetrospectivecasestudy
AT sakaitomoyuki longtermsurvivalbysurgeryandadjuvantchemotherapyinapatientwithperforatedextranodalnktcelllymphomaofthesmallintestinearetrospectivecasestudy
AT yamadasohsuke longtermsurvivalbysurgeryandadjuvantchemotherapyinapatientwithperforatedextranodalnktcelllymphomaofthesmallintestinearetrospectivecasestudy
AT masakiyasufumi longtermsurvivalbysurgeryandadjuvantchemotherapyinapatientwithperforatedextranodalnktcelllymphomaofthesmallintestinearetrospectivecasestudy