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The WASH-complex subunit Strumpellin regulates integrin αIIbβ3 trafficking in murine platelets

The platelet specific integrin αIIbβ3 mediates platelet adhesion, aggregation and plays a central role in thrombosis and hemostasis. In resting platelets, αIIbβ3 is expressed on the membrane surface and in intracellular compartments. Upon activation, the number of surface-expressed αIIbβ3 is increas...

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Detalles Bibliográficos
Autores principales:	Schurr, Yvonne, Reil, Lucy, Spindler, Markus, Nieswandt, Bernhard, Machesky, Laura M., Bender, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260982/ https://www.ncbi.nlm.nih.gov/pubmed/37308549 http://dx.doi.org/10.1038/s41598-023-36387-8

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