Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis

The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A and TNF inflammatory responses in the absence of neutrophil...

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Detalles Bibliográficos
Autores principales: Ma, Feiyang, Plazyo, Olesya, Billi, Allison C., Tsoi, Lam C., Xing, Xianying, Wasikowski, Rachael, Gharaee-Kermani, Mehrnaz, Hile, Grace, Jiang, Yanyun, Harms, Paul W., Xing, Enze, Kirma, Joseph, Xi, Jingyue, Hsu, Jer-En, Sarkar, Mrinal K., Chung, Yutein, Di Domizio, Jeremy, Gilliet, Michel, Ward, Nicole L., Maverakis, Emanual, Klechevsky, Eynav, Voorhees, John J., Elder, James T., Lee, Jun Hee, Kahlenberg, J. Michelle, Pellegrini, Matteo, Modlin, Robert L., Gudjonsson, Johann E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261041/
https://www.ncbi.nlm.nih.gov/pubmed/37308489
http://dx.doi.org/10.1038/s41467-023-39020-4

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