Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design

Malaria results in more than 500,000 deaths per year and the causative Plasmodium parasites continue to develop resistance to all known agents, including different antimalarial combinations. The class XIV myosin motor PfMyoA is part of a core macromolecular complex called the glideosome, essential f...

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Detalles Bibliográficos
Autores principales: Moussaoui, Dihia, Robblee, James P., Robert-Paganin, Julien, Auguin, Daniel, Fisher, Fabio, Fagnant, Patricia M., Macfarlane, Jill E., Schaletzky, Julia, Wehri, Eddie, Mueller-Dieckmann, Christoph, Baum, Jake, Trybus, Kathleen M., Houdusse, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261046/
https://www.ncbi.nlm.nih.gov/pubmed/37308472
http://dx.doi.org/10.1038/s41467-023-38976-7

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