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Individualized active surveillance for carbapenem-resistant microorganisms using Xpert Carba-R in intensive care units

Carbapenem antibiotics are widely used in ICU, and the prevalence of carbapenem-resistant microorganisms (CRO) has increased. This study aimed to assess the role of individualized active surveillance using Xpert Carba-R of carbapenem resistance genes on CRO risk. A total of 3,765 patients were admit...

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Autores principales: Zhou, Shuliang, Mi, Sulin, Rao, Xin, Zhang, Qi, Wei, Shiwen, Xiao, Meng, Peng, Zhiyong, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261131/
https://www.ncbi.nlm.nih.gov/pubmed/37308521
http://dx.doi.org/10.1038/s41598-023-36321-y
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author Zhou, Shuliang
Mi, Sulin
Rao, Xin
Zhang, Qi
Wei, Shiwen
Xiao, Meng
Peng, Zhiyong
Wang, Jing
author_facet Zhou, Shuliang
Mi, Sulin
Rao, Xin
Zhang, Qi
Wei, Shiwen
Xiao, Meng
Peng, Zhiyong
Wang, Jing
author_sort Zhou, Shuliang
collection PubMed
description Carbapenem antibiotics are widely used in ICU, and the prevalence of carbapenem-resistant microorganisms (CRO) has increased. This study aimed to assess the role of individualized active surveillance using Xpert Carba-R of carbapenem resistance genes on CRO risk. A total of 3,765 patients were admitted to the ICU of Zhongnan Hospital of Wuhan University between 2020 and 2022. The presence of carbapenem resistance genes were monitored using Xpert Carba-R, and CRO incidence was assigned as the investigated outcome. Of 3,765 patients, 390 manifested the presence of CRO, representing a prevalence of 10.36%. Active surveillance using Xpert Carba-R was associated with a lower CRO risk (odds ratio [OR]: 0.77; 95% confidence interval [CI] 0.62–0.95; P = 0.013), especially for carbapenem-resistant Acinetobacter + carbapenem-resistant Pseudomonas aeruginosa (OR: 0.79; 95% CI 0.62–0.99; P = 0.043), carbapenem-resistant Klebsiella pneumoniae (OR: 0.56; 95% CI 0.40–0.79; P = 0.001), and carbapenem-resistant Enterobacteriaceae (OR: 0.65; 95% CI 0.47–0.90; P = 0.008). Individualized active surveillance using Xpert Carba-R may be associated with a reduction in the overall CRO incidence in ICU. Further prospective studies should be performed to verify these conclusions and guide further management of patients in ICU.
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spelling pubmed-102611312023-06-15 Individualized active surveillance for carbapenem-resistant microorganisms using Xpert Carba-R in intensive care units Zhou, Shuliang Mi, Sulin Rao, Xin Zhang, Qi Wei, Shiwen Xiao, Meng Peng, Zhiyong Wang, Jing Sci Rep Article Carbapenem antibiotics are widely used in ICU, and the prevalence of carbapenem-resistant microorganisms (CRO) has increased. This study aimed to assess the role of individualized active surveillance using Xpert Carba-R of carbapenem resistance genes on CRO risk. A total of 3,765 patients were admitted to the ICU of Zhongnan Hospital of Wuhan University between 2020 and 2022. The presence of carbapenem resistance genes were monitored using Xpert Carba-R, and CRO incidence was assigned as the investigated outcome. Of 3,765 patients, 390 manifested the presence of CRO, representing a prevalence of 10.36%. Active surveillance using Xpert Carba-R was associated with a lower CRO risk (odds ratio [OR]: 0.77; 95% confidence interval [CI] 0.62–0.95; P = 0.013), especially for carbapenem-resistant Acinetobacter + carbapenem-resistant Pseudomonas aeruginosa (OR: 0.79; 95% CI 0.62–0.99; P = 0.043), carbapenem-resistant Klebsiella pneumoniae (OR: 0.56; 95% CI 0.40–0.79; P = 0.001), and carbapenem-resistant Enterobacteriaceae (OR: 0.65; 95% CI 0.47–0.90; P = 0.008). Individualized active surveillance using Xpert Carba-R may be associated with a reduction in the overall CRO incidence in ICU. Further prospective studies should be performed to verify these conclusions and guide further management of patients in ICU. Nature Publishing Group UK 2023-06-12 /pmc/articles/PMC10261131/ /pubmed/37308521 http://dx.doi.org/10.1038/s41598-023-36321-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhou, Shuliang
Mi, Sulin
Rao, Xin
Zhang, Qi
Wei, Shiwen
Xiao, Meng
Peng, Zhiyong
Wang, Jing
Individualized active surveillance for carbapenem-resistant microorganisms using Xpert Carba-R in intensive care units
title Individualized active surveillance for carbapenem-resistant microorganisms using Xpert Carba-R in intensive care units
title_full Individualized active surveillance for carbapenem-resistant microorganisms using Xpert Carba-R in intensive care units
title_fullStr Individualized active surveillance for carbapenem-resistant microorganisms using Xpert Carba-R in intensive care units
title_full_unstemmed Individualized active surveillance for carbapenem-resistant microorganisms using Xpert Carba-R in intensive care units
title_short Individualized active surveillance for carbapenem-resistant microorganisms using Xpert Carba-R in intensive care units
title_sort individualized active surveillance for carbapenem-resistant microorganisms using xpert carba-r in intensive care units
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261131/
https://www.ncbi.nlm.nih.gov/pubmed/37308521
http://dx.doi.org/10.1038/s41598-023-36321-y
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