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Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis

The ORM/ORMDL family proteins function as regulatory subunits of the serine palmitoyltransferase (SPT) complex, which is the initiating and rate-limiting enzyme in sphingolipid biosynthesis. This complex is tightly regulated by cellular sphingolipid levels, but the sphingolipid sensing mechanism is...

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Detalles Bibliográficos
Autores principales:	Xie, Tian, Liu, Peng, Wu, Xinyue, Dong, Feitong, Zhang, Zike, Yue, Jian, Mahawar, Usha, Farooq, Faheem, Vohra, Hisham, Fang, Qi, Liu, Wenchen, Wattenberg, Binks W., Gong, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261145/ https://www.ncbi.nlm.nih.gov/pubmed/37308477 http://dx.doi.org/10.1038/s41467-023-39274-y

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