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Relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees
PURPOSE: Sarcopenia and delayed orthostatic blood pressure (BP) recovery are two disorders increasingly associated with adverse clinical outcomes in older adults. There may exist a pathophysiological link between the two via the skeletal muscle pump of the lower limbs. Previously in a large populati...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261219/ https://www.ncbi.nlm.nih.gov/pubmed/37029293 http://dx.doi.org/10.1007/s41999-023-00775-0 |
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author | Duggan, Eoin Knight, Silvin P. Romero-Ortuno, Roman |
author_facet | Duggan, Eoin Knight, Silvin P. Romero-Ortuno, Roman |
author_sort | Duggan, Eoin |
collection | PubMed |
description | PURPOSE: Sarcopenia and delayed orthostatic blood pressure (BP) recovery are two disorders increasingly associated with adverse clinical outcomes in older adults. There may exist a pathophysiological link between the two via the skeletal muscle pump of the lower limbs. Previously in a large population-based study, we found an association between probable sarcopenia and orthostatic BP recovery. Here, we sought to determine the association between confirmed sarcopenia and orthostatic BP recovery in falls clinic attendees aged 50 years or over. METHODS: One hundred and nine recruited patients (mean age 70 years, 58% women) underwent an active stand with non-invasive beat-to-beat haemodynamic monitoring. Hand grip strength and five-chair stands time were measured, and bioelectrical impedance analysis was performed. They were then classified as robust, probable sarcopenic or sarcopenic as per the European Working Group on Sarcopenia in Older People guidelines. Mixed effects models with linear splines were used to model the effect of sarcopenia status on orthostatic BP recovery, whilst controlling for potential confounders. RESULTS: Probable sarcopenia was identified in 32% of the sample and sarcopenia in 15%. Both probable and confirmed sarcopenia were independently associated with an attenuated rate of recovery of both systolic and diastolic BP in the 10–20 s period after standing. Attenuation was larger for confirmed than probable sarcopenia (systolic BP β − 0.85 and − 0.59, respectively, P < 0.01; diastolic BP β − 0.65, − 0.45, P < 0.001). CONCLUSION: Sarcopenia was independently associated with slower BP recovery during the early post-stand period. The potentially modifiable effect of the skeletal muscle pump in orthostatic haemodynamics requires further study. |
format | Online Article Text |
id | pubmed-10261219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-102612192023-06-15 Relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees Duggan, Eoin Knight, Silvin P. Romero-Ortuno, Roman Eur Geriatr Med Research Paper PURPOSE: Sarcopenia and delayed orthostatic blood pressure (BP) recovery are two disorders increasingly associated with adverse clinical outcomes in older adults. There may exist a pathophysiological link between the two via the skeletal muscle pump of the lower limbs. Previously in a large population-based study, we found an association between probable sarcopenia and orthostatic BP recovery. Here, we sought to determine the association between confirmed sarcopenia and orthostatic BP recovery in falls clinic attendees aged 50 years or over. METHODS: One hundred and nine recruited patients (mean age 70 years, 58% women) underwent an active stand with non-invasive beat-to-beat haemodynamic monitoring. Hand grip strength and five-chair stands time were measured, and bioelectrical impedance analysis was performed. They were then classified as robust, probable sarcopenic or sarcopenic as per the European Working Group on Sarcopenia in Older People guidelines. Mixed effects models with linear splines were used to model the effect of sarcopenia status on orthostatic BP recovery, whilst controlling for potential confounders. RESULTS: Probable sarcopenia was identified in 32% of the sample and sarcopenia in 15%. Both probable and confirmed sarcopenia were independently associated with an attenuated rate of recovery of both systolic and diastolic BP in the 10–20 s period after standing. Attenuation was larger for confirmed than probable sarcopenia (systolic BP β − 0.85 and − 0.59, respectively, P < 0.01; diastolic BP β − 0.65, − 0.45, P < 0.001). CONCLUSION: Sarcopenia was independently associated with slower BP recovery during the early post-stand period. The potentially modifiable effect of the skeletal muscle pump in orthostatic haemodynamics requires further study. Springer International Publishing 2023-04-08 2023 /pmc/articles/PMC10261219/ /pubmed/37029293 http://dx.doi.org/10.1007/s41999-023-00775-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Paper Duggan, Eoin Knight, Silvin P. Romero-Ortuno, Roman Relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees |
title | Relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees |
title_full | Relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees |
title_fullStr | Relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees |
title_full_unstemmed | Relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees |
title_short | Relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees |
title_sort | relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261219/ https://www.ncbi.nlm.nih.gov/pubmed/37029293 http://dx.doi.org/10.1007/s41999-023-00775-0 |
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