Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology

Inhibition of phosphodiesterase 4D (PDE4D) enzymes has been investigated as therapeutic strategy to treat memory problems in Alzheimer’s disease (AD). Although PDE4D inhibitors are effective in enhancing memory processes in rodents and humans, severe side effects may hamper their clinical use. PDE4D...

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Detalles Bibliográficos
Autores principales: Paes, Dean, Schepers, Melissa, Willems, Emily, Rombaut, Ben, Tiane, Assia, Solomina, Yevgeniya, Tibbo, Amy, Blair, Connor, Kyurkchieva, Elka, Baillie, George S., Ricciarelli, Roberta, Brullo, Chiara, Fedele, Ernesto, Bruno, Olga, van den Hove, Daniel, Vanmierlo, Tim, Prickaerts, Jos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261250/
https://www.ncbi.nlm.nih.gov/pubmed/37306762
http://dx.doi.org/10.1007/s00018-023-04804-w

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