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[(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants
[(68)Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Mashhad University of Medical Sciences
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261692/ https://www.ncbi.nlm.nih.gov/pubmed/37324227 http://dx.doi.org/10.22038/AOJNMB.2022.66223.1458 |
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author | Roustaei, Hessamoddin Askari, Emran Barashki, Somayeh Anvari, Kazem Sadeghi, Ramin Aryana, Kamran |
author_facet | Roustaei, Hessamoddin Askari, Emran Barashki, Somayeh Anvari, Kazem Sadeghi, Ramin Aryana, Kamran |
author_sort | Roustaei, Hessamoddin |
collection | PubMed |
description | [(68)Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the affected tumoral cells. Healthy and non-affected organ cells express low-level CXCR4 ligands density. We performed [(68)Ga] Ga-Pentixafor (Pars-Cixafor™) PET/CT in a patient with high-grade Glioma (anaplastic oligodendroglioma WHO grade III) with no other documented medical condition and history. In addition to the Pentixafor-avid tumor remnant in the PET/CT images, we observed mild symmetrical bilateral uptake in the fibro glandular tissue of the breasts and moderate CXCR4(Pentixafor) avidity in both adrenal glands without any discernable pathology and abnormal density changes in the CT component of the study. Attention should be paid to the interpreting [(68)Ga] Ga-Pentixafor PET/CT examination and its normal uptakes and variants. |
format | Online Article Text |
id | pubmed-10261692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-102616922023-06-15 [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants Roustaei, Hessamoddin Askari, Emran Barashki, Somayeh Anvari, Kazem Sadeghi, Ramin Aryana, Kamran Asia Ocean J Nucl Med Biol Case Report [(68)Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the affected tumoral cells. Healthy and non-affected organ cells express low-level CXCR4 ligands density. We performed [(68)Ga] Ga-Pentixafor (Pars-Cixafor™) PET/CT in a patient with high-grade Glioma (anaplastic oligodendroglioma WHO grade III) with no other documented medical condition and history. In addition to the Pentixafor-avid tumor remnant in the PET/CT images, we observed mild symmetrical bilateral uptake in the fibro glandular tissue of the breasts and moderate CXCR4(Pentixafor) avidity in both adrenal glands without any discernable pathology and abnormal density changes in the CT component of the study. Attention should be paid to the interpreting [(68)Ga] Ga-Pentixafor PET/CT examination and its normal uptakes and variants. Mashhad University of Medical Sciences 2023 /pmc/articles/PMC10261692/ /pubmed/37324227 http://dx.doi.org/10.22038/AOJNMB.2022.66223.1458 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Roustaei, Hessamoddin Askari, Emran Barashki, Somayeh Anvari, Kazem Sadeghi, Ramin Aryana, Kamran [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
title | [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
title_full | [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
title_fullStr | [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
title_full_unstemmed | [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
title_short | [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
title_sort | [(68)ga] ga-pentixafor diffuse bilateral adrenal & breast uptake in a patient with high-grade glioma: a note of caution on normal variants |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261692/ https://www.ncbi.nlm.nih.gov/pubmed/37324227 http://dx.doi.org/10.22038/AOJNMB.2022.66223.1458 |
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