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[(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants

[(68)Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the...

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Autores principales: Roustaei, Hessamoddin, Askari, Emran, Barashki, Somayeh, Anvari, Kazem, Sadeghi, Ramin, Aryana, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261692/
https://www.ncbi.nlm.nih.gov/pubmed/37324227
http://dx.doi.org/10.22038/AOJNMB.2022.66223.1458
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author Roustaei, Hessamoddin
Askari, Emran
Barashki, Somayeh
Anvari, Kazem
Sadeghi, Ramin
Aryana, Kamran
author_facet Roustaei, Hessamoddin
Askari, Emran
Barashki, Somayeh
Anvari, Kazem
Sadeghi, Ramin
Aryana, Kamran
author_sort Roustaei, Hessamoddin
collection PubMed
description [(68)Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the affected tumoral cells. Healthy and non-affected organ cells express low-level CXCR4 ligands density. We performed [(68)Ga] Ga-Pentixafor (Pars-Cixafor™) PET/CT in a patient with high-grade Glioma (anaplastic oligodendroglioma WHO grade III) with no other documented medical condition and history. In addition to the Pentixafor-avid tumor remnant in the PET/CT images, we observed mild symmetrical bilateral uptake in the fibro glandular tissue of the breasts and moderate CXCR4(Pentixafor) avidity in both adrenal glands without any discernable pathology and abnormal density changes in the CT component of the study. Attention should be paid to the interpreting [(68)Ga] Ga-Pentixafor PET/CT examination and its normal uptakes and variants.
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spelling pubmed-102616922023-06-15 [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants Roustaei, Hessamoddin Askari, Emran Barashki, Somayeh Anvari, Kazem Sadeghi, Ramin Aryana, Kamran Asia Ocean J Nucl Med Biol Case Report [(68)Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the affected tumoral cells. Healthy and non-affected organ cells express low-level CXCR4 ligands density. We performed [(68)Ga] Ga-Pentixafor (Pars-Cixafor™) PET/CT in a patient with high-grade Glioma (anaplastic oligodendroglioma WHO grade III) with no other documented medical condition and history. In addition to the Pentixafor-avid tumor remnant in the PET/CT images, we observed mild symmetrical bilateral uptake in the fibro glandular tissue of the breasts and moderate CXCR4(Pentixafor) avidity in both adrenal glands without any discernable pathology and abnormal density changes in the CT component of the study. Attention should be paid to the interpreting [(68)Ga] Ga-Pentixafor PET/CT examination and its normal uptakes and variants. Mashhad University of Medical Sciences 2023 /pmc/articles/PMC10261692/ /pubmed/37324227 http://dx.doi.org/10.22038/AOJNMB.2022.66223.1458 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Roustaei, Hessamoddin
Askari, Emran
Barashki, Somayeh
Anvari, Kazem
Sadeghi, Ramin
Aryana, Kamran
[(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants
title [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants
title_full [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants
title_fullStr [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants
title_full_unstemmed [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants
title_short [(68)Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants
title_sort [(68)ga] ga-pentixafor diffuse bilateral adrenal & breast uptake in a patient with high-grade glioma: a note of caution on normal variants
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261692/
https://www.ncbi.nlm.nih.gov/pubmed/37324227
http://dx.doi.org/10.22038/AOJNMB.2022.66223.1458
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