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Seroprevalence of SARS-CoV-2 in Brazil: A systematic review and meta-analysis

OBJECTIVES: To summarize the data on SARS-CoV-2 seroprevalence surveys conducted in Brazil before the introduction of vaccines METHODS: The authors conducted a systematic review and meta-analysis on the seroprevalence of SARS-CoV-2 infection in Brazil. The present review followed the PRISMA guidelin...

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Autores principales: Figueiredo, Gerusa Maria, Tengan, Fátima Mitiko, Campos, Sergio Roberto, Luna, Expedito José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261714/
https://www.ncbi.nlm.nih.gov/pubmed/37348256
http://dx.doi.org/10.1016/j.clinsp.2023.100233
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author Figueiredo, Gerusa Maria
Tengan, Fátima Mitiko
Campos, Sergio Roberto
Luna, Expedito José
author_facet Figueiredo, Gerusa Maria
Tengan, Fátima Mitiko
Campos, Sergio Roberto
Luna, Expedito José
author_sort Figueiredo, Gerusa Maria
collection PubMed
description OBJECTIVES: To summarize the data on SARS-CoV-2 seroprevalence surveys conducted in Brazil before the introduction of vaccines METHODS: The authors conducted a systematic review and meta-analysis on the seroprevalence of SARS-CoV-2 infection in Brazil. The present review followed the PRISMA guidelines. The authors searched Medline, Embase, and LILACS databases for serologic surveys conducted in the Brazilian population, in the period from 01/10/2019 to 07/11/2021, without language restrictions. The authors included studies that presented data concerning SARS-CoV-2 antibodies seroprevalence in Brazil and had a sample size ≥50 individuals. Considering the expected heterogeneity between studies, all analyses were performed using the random effects model, and heterogeneity was assessed using the I(2) statistic RESULTS: Of 586 publications identified in the initial searches, 54 were included in the review and meta-analysis, which contained the results of 135 surveys, with 336,620 participants. The estimated seroprevalence was 11.0%, ranging from 1.0% to 83.0%, with a substantial heterogeneity (I(2) = 99.55%). In subgroup analyses, the authors observed that the prevalence of SARS-CoV-2 antibodies was 13.0% in blood donors, 9.0% in the population-based surveys, 13% in schoolchildren, and 11.0% in healthcare workers. CONCLUSIONS: Seroprevalence increases over time. Large differences were observed among the regions of the country. It was higher in the Northern region, decreasing towards the South. The present results may contribute to the analysis of the spread of SARS-CoV-2 infection in the Brazilian population before vaccination, one of the factors that may be influencing the clinical presentation of COVID-19 cases related to the new variants, as well as the effectiveness of the vaccination program.
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spelling pubmed-102617142023-06-14 Seroprevalence of SARS-CoV-2 in Brazil: A systematic review and meta-analysis Figueiredo, Gerusa Maria Tengan, Fátima Mitiko Campos, Sergio Roberto Luna, Expedito José Clinics (Sao Paulo) Original Articles OBJECTIVES: To summarize the data on SARS-CoV-2 seroprevalence surveys conducted in Brazil before the introduction of vaccines METHODS: The authors conducted a systematic review and meta-analysis on the seroprevalence of SARS-CoV-2 infection in Brazil. The present review followed the PRISMA guidelines. The authors searched Medline, Embase, and LILACS databases for serologic surveys conducted in the Brazilian population, in the period from 01/10/2019 to 07/11/2021, without language restrictions. The authors included studies that presented data concerning SARS-CoV-2 antibodies seroprevalence in Brazil and had a sample size ≥50 individuals. Considering the expected heterogeneity between studies, all analyses were performed using the random effects model, and heterogeneity was assessed using the I(2) statistic RESULTS: Of 586 publications identified in the initial searches, 54 were included in the review and meta-analysis, which contained the results of 135 surveys, with 336,620 participants. The estimated seroprevalence was 11.0%, ranging from 1.0% to 83.0%, with a substantial heterogeneity (I(2) = 99.55%). In subgroup analyses, the authors observed that the prevalence of SARS-CoV-2 antibodies was 13.0% in blood donors, 9.0% in the population-based surveys, 13% in schoolchildren, and 11.0% in healthcare workers. CONCLUSIONS: Seroprevalence increases over time. Large differences were observed among the regions of the country. It was higher in the Northern region, decreasing towards the South. The present results may contribute to the analysis of the spread of SARS-CoV-2 infection in the Brazilian population before vaccination, one of the factors that may be influencing the clinical presentation of COVID-19 cases related to the new variants, as well as the effectiveness of the vaccination program. Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo 2023-06-13 /pmc/articles/PMC10261714/ /pubmed/37348256 http://dx.doi.org/10.1016/j.clinsp.2023.100233 Text en © 2023 HCFMUSP. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Articles
Figueiredo, Gerusa Maria
Tengan, Fátima Mitiko
Campos, Sergio Roberto
Luna, Expedito José
Seroprevalence of SARS-CoV-2 in Brazil: A systematic review and meta-analysis
title Seroprevalence of SARS-CoV-2 in Brazil: A systematic review and meta-analysis
title_full Seroprevalence of SARS-CoV-2 in Brazil: A systematic review and meta-analysis
title_fullStr Seroprevalence of SARS-CoV-2 in Brazil: A systematic review and meta-analysis
title_full_unstemmed Seroprevalence of SARS-CoV-2 in Brazil: A systematic review and meta-analysis
title_short Seroprevalence of SARS-CoV-2 in Brazil: A systematic review and meta-analysis
title_sort seroprevalence of sars-cov-2 in brazil: a systematic review and meta-analysis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261714/
https://www.ncbi.nlm.nih.gov/pubmed/37348256
http://dx.doi.org/10.1016/j.clinsp.2023.100233
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