Cargando…
Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells
The accumulation of foam cells in arterial intima and the accompanied chronic inflammation are considered major causes of neoatherosclerosis and restenosis. However, both the underlying mechanism and effective treatment for the disease are yet to be uncovered. In this study, we combined transcriptom...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261774/ https://www.ncbi.nlm.nih.gov/pubmed/37324843 http://dx.doi.org/10.1002/fsn3.3296 |
_version_ | 1785057939650772992 |
---|---|
author | Liu, Yuting Wang, Kefan Yang, Shuofei Xue, Guanhua Lu, Liming |
author_facet | Liu, Yuting Wang, Kefan Yang, Shuofei Xue, Guanhua Lu, Liming |
author_sort | Liu, Yuting |
collection | PubMed |
description | The accumulation of foam cells in arterial intima and the accompanied chronic inflammation are considered major causes of neoatherosclerosis and restenosis. However, both the underlying mechanism and effective treatment for the disease are yet to be uncovered. In this study, we combined transcriptome profiling of restenosis artery tissue and bioinformatic analysis to reveal that NLRP3 inflammasome is markedly upregulated in restenosis and that several restenosis‐related DEGs are also targets of mulberry extract, a natural dietary supplement used in traditional Chinese medicine. We demonstrated that mulberry extract suppresses the formation of ox‐LDL‐induced foam cells, possibly by upregulating the cholesterol efflux genes ABCA1 and ABCG1 to inhibit intracellular lipid accumulation. In addition, mulberry extract dampens NLRP3 inflammasome activation by stressing the MAPK signaling pathway. These findings unveil the therapeutic value of mulberry extract in neoatherosclerosis and restenosis treatment by regulating lipid metabolism and inflammatory response of foam cells. |
format | Online Article Text |
id | pubmed-10261774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102617742023-06-15 Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells Liu, Yuting Wang, Kefan Yang, Shuofei Xue, Guanhua Lu, Liming Food Sci Nutr Original Articles The accumulation of foam cells in arterial intima and the accompanied chronic inflammation are considered major causes of neoatherosclerosis and restenosis. However, both the underlying mechanism and effective treatment for the disease are yet to be uncovered. In this study, we combined transcriptome profiling of restenosis artery tissue and bioinformatic analysis to reveal that NLRP3 inflammasome is markedly upregulated in restenosis and that several restenosis‐related DEGs are also targets of mulberry extract, a natural dietary supplement used in traditional Chinese medicine. We demonstrated that mulberry extract suppresses the formation of ox‐LDL‐induced foam cells, possibly by upregulating the cholesterol efflux genes ABCA1 and ABCG1 to inhibit intracellular lipid accumulation. In addition, mulberry extract dampens NLRP3 inflammasome activation by stressing the MAPK signaling pathway. These findings unveil the therapeutic value of mulberry extract in neoatherosclerosis and restenosis treatment by regulating lipid metabolism and inflammatory response of foam cells. John Wiley and Sons Inc. 2023-03-08 /pmc/articles/PMC10261774/ /pubmed/37324843 http://dx.doi.org/10.1002/fsn3.3296 Text en © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Liu, Yuting Wang, Kefan Yang, Shuofei Xue, Guanhua Lu, Liming Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells |
title | Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells |
title_full | Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells |
title_fullStr | Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells |
title_full_unstemmed | Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells |
title_short | Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells |
title_sort | mulberry extract upregulates cholesterol efflux and inhibits p38 mapk‐nlrp3‐mediated inflammation in foam cells |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261774/ https://www.ncbi.nlm.nih.gov/pubmed/37324843 http://dx.doi.org/10.1002/fsn3.3296 |
work_keys_str_mv | AT liuyuting mulberryextractupregulatescholesteroleffluxandinhibitsp38mapknlrp3mediatedinflammationinfoamcells AT wangkefan mulberryextractupregulatescholesteroleffluxandinhibitsp38mapknlrp3mediatedinflammationinfoamcells AT yangshuofei mulberryextractupregulatescholesteroleffluxandinhibitsp38mapknlrp3mediatedinflammationinfoamcells AT xueguanhua mulberryextractupregulatescholesteroleffluxandinhibitsp38mapknlrp3mediatedinflammationinfoamcells AT luliming mulberryextractupregulatescholesteroleffluxandinhibitsp38mapknlrp3mediatedinflammationinfoamcells |