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Gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity
Sarcopenia and obesity are emerging as major social problems. In this study, we examined whether Gryllus bimaculatus (GB), an edible insect, prevents dexamethasone‐induced muscle atrophy (sarcopenia) or high‐fat diet (HFD)‐induced obesity in mice. We generated a standard chow diet (SCD) + GB (85% SC...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261823/ https://www.ncbi.nlm.nih.gov/pubmed/37324877 http://dx.doi.org/10.1002/fsn3.3257 |
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author | Kim, Min Hee Kim, Su‐Jeong Kim, Si‐Hyun Park, Woo‐Jae Han, Jung‐Soon |
author_facet | Kim, Min Hee Kim, Su‐Jeong Kim, Si‐Hyun Park, Woo‐Jae Han, Jung‐Soon |
author_sort | Kim, Min Hee |
collection | PubMed |
description | Sarcopenia and obesity are emerging as major social problems. In this study, we examined whether Gryllus bimaculatus (GB), an edible insect, prevents dexamethasone‐induced muscle atrophy (sarcopenia) or high‐fat diet (HFD)‐induced obesity in mice. We generated a standard chow diet (SCD) + GB (85% SCD and 15% GB powder) and HFD + GB (85% HFD and 15% GB powder). SCD + GB feeding increased gains in body weight and white adipose tissue (WAT). Despite no difference in weight change between HFD + GB‐ and HFD‐fed mice, HFD + GB feeding aggravated insulin resistance compared with HFD feeding. SCD + GB or HFD + GB feeding did not change most gene expressions in the liver and WAT but did increase MyHC1 expression in the muscle, meaning that GB increased muscle generation. Therefore, we fed SCD + GB with dexamethasone, which induces muscle degeneration. As a result, muscle fiber size increased, as did grip strength compared with dexamethasone‐injected mice. In addition, SCD + GB reduced the expression of muscle degradation factors, such as atrogin1 and muscle RING‐finger protein 1 (MuRF1). Furthermore, SCD + GB feeding increased Akt, mTOR, and p70S6K phosphorylation and MyHC1 expression, meaning that it may have increased protein synthesis. In conclusion, GB has great potential for inhibiting dexamethasone‐induced muscle mass loss by increasing muscle protein synthesis and inhibiting muscle protein degradation. |
format | Online Article Text |
id | pubmed-10261823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102618232023-06-15 Gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity Kim, Min Hee Kim, Su‐Jeong Kim, Si‐Hyun Park, Woo‐Jae Han, Jung‐Soon Food Sci Nutr Original Articles Sarcopenia and obesity are emerging as major social problems. In this study, we examined whether Gryllus bimaculatus (GB), an edible insect, prevents dexamethasone‐induced muscle atrophy (sarcopenia) or high‐fat diet (HFD)‐induced obesity in mice. We generated a standard chow diet (SCD) + GB (85% SCD and 15% GB powder) and HFD + GB (85% HFD and 15% GB powder). SCD + GB feeding increased gains in body weight and white adipose tissue (WAT). Despite no difference in weight change between HFD + GB‐ and HFD‐fed mice, HFD + GB feeding aggravated insulin resistance compared with HFD feeding. SCD + GB or HFD + GB feeding did not change most gene expressions in the liver and WAT but did increase MyHC1 expression in the muscle, meaning that GB increased muscle generation. Therefore, we fed SCD + GB with dexamethasone, which induces muscle degeneration. As a result, muscle fiber size increased, as did grip strength compared with dexamethasone‐injected mice. In addition, SCD + GB reduced the expression of muscle degradation factors, such as atrogin1 and muscle RING‐finger protein 1 (MuRF1). Furthermore, SCD + GB feeding increased Akt, mTOR, and p70S6K phosphorylation and MyHC1 expression, meaning that it may have increased protein synthesis. In conclusion, GB has great potential for inhibiting dexamethasone‐induced muscle mass loss by increasing muscle protein synthesis and inhibiting muscle protein degradation. John Wiley and Sons Inc. 2023-02-04 /pmc/articles/PMC10261823/ /pubmed/37324877 http://dx.doi.org/10.1002/fsn3.3257 Text en © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Kim, Min Hee Kim, Su‐Jeong Kim, Si‐Hyun Park, Woo‐Jae Han, Jung‐Soon Gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity |
title |
Gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity |
title_full |
Gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity |
title_fullStr |
Gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity |
title_full_unstemmed |
Gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity |
title_short |
Gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity |
title_sort | gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261823/ https://www.ncbi.nlm.nih.gov/pubmed/37324877 http://dx.doi.org/10.1002/fsn3.3257 |
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