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Recent advances in electrochemical determination of anticancer drug 5-fluorouracil

Reliable, rapid, highly selective and sensitive analytical methods for the determination of antineoplastic agent 5-fluorouracil (5-FU) in human body fluids (blood serum/plasma and urine) are required to improve the chemotherapy regimen to reduce its toxicity and improve efficacy. Nowadays, electroch...

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Detalles Bibliográficos
Autores principales: Dodevska, Totka, Hadzhiev, Dobrin, Shterev, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association of Physical Chemists 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262222/
https://www.ncbi.nlm.nih.gov/pubmed/37325113
http://dx.doi.org/10.5599/admet.1711
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author Dodevska, Totka
Hadzhiev, Dobrin
Shterev, Ivan
author_facet Dodevska, Totka
Hadzhiev, Dobrin
Shterev, Ivan
author_sort Dodevska, Totka
collection PubMed
description Reliable, rapid, highly selective and sensitive analytical methods for the determination of antineoplastic agent 5-fluorouracil (5-FU) in human body fluids (blood serum/plasma and urine) are required to improve the chemotherapy regimen to reduce its toxicity and improve efficacy. Nowadays, electrochemical techniques provide a powerful analytical tool for 5-FU detection systems. This comprehensive review covers the advances in the development of electrochemical sensors for the quantitative determination of 5-FU, mainly focused on original studies reported from 2015 to date. We have summarized recent trends in the electrochemical sensor systems applied for the analysis of 5-FU in pharmaceutical formulations and biological samples, and critically evaluated the key performance metrics of these sensors (limit of detection, linear range, stability and recovery). Challenges and future outlooks in this field have also been discussed.
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spelling pubmed-102622222023-06-15 Recent advances in electrochemical determination of anticancer drug 5-fluorouracil Dodevska, Totka Hadzhiev, Dobrin Shterev, Ivan ADMET DMPK Review Reliable, rapid, highly selective and sensitive analytical methods for the determination of antineoplastic agent 5-fluorouracil (5-FU) in human body fluids (blood serum/plasma and urine) are required to improve the chemotherapy regimen to reduce its toxicity and improve efficacy. Nowadays, electrochemical techniques provide a powerful analytical tool for 5-FU detection systems. This comprehensive review covers the advances in the development of electrochemical sensors for the quantitative determination of 5-FU, mainly focused on original studies reported from 2015 to date. We have summarized recent trends in the electrochemical sensor systems applied for the analysis of 5-FU in pharmaceutical formulations and biological samples, and critically evaluated the key performance metrics of these sensors (limit of detection, linear range, stability and recovery). Challenges and future outlooks in this field have also been discussed. International Association of Physical Chemists 2023-04-19 /pmc/articles/PMC10262222/ /pubmed/37325113 http://dx.doi.org/10.5599/admet.1711 Text en Copyright © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Dodevska, Totka
Hadzhiev, Dobrin
Shterev, Ivan
Recent advances in electrochemical determination of anticancer drug 5-fluorouracil
title Recent advances in electrochemical determination of anticancer drug 5-fluorouracil
title_full Recent advances in electrochemical determination of anticancer drug 5-fluorouracil
title_fullStr Recent advances in electrochemical determination of anticancer drug 5-fluorouracil
title_full_unstemmed Recent advances in electrochemical determination of anticancer drug 5-fluorouracil
title_short Recent advances in electrochemical determination of anticancer drug 5-fluorouracil
title_sort recent advances in electrochemical determination of anticancer drug 5-fluorouracil
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262222/
https://www.ncbi.nlm.nih.gov/pubmed/37325113
http://dx.doi.org/10.5599/admet.1711
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