Determination of salicylic acid content in pharmaceuticals using chitosan@Fe(3)O(4)/CPE electrode detected by SWV technique

Chitosan-coated magnetite nanoparticles (Chitosan@Fe(3)O(4)) were used to modify the carbon paste electrode (Chitosan@Fe(3)O(4)/CPE) to enhance sensitivity for salicylic acid (SA) analysis using square wave voltammetry (SWV). The performance and behaviour of the purposed electrodes were investigated using cyclic voltammetry (CV). The results showed that the mixed behaviour process was observed. Furthermore, parameters affecting SWV were also studied. It was discovered that the optimum conditions were a two-linearity range of SA determination, 1-100 and 100-400 μM. The limit of detection (LOD) and the limit of quantitation (LOQ) for SA are 0.57 μM and 0.90 μM, respectively. The proposed electrodes were successfully used to determine SA in applications employing pharmaceutical samples.