Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior

Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study...

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Autores principales: Mirfazeli, Fatemeh Sadat, Mohebi, Fatemeh, Jahanbakhshi, Amin, Aryani, Omid, Almasi-Dooghaee, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262289/
https://www.ncbi.nlm.nih.gov/pubmed/37323959
http://dx.doi.org/10.32598/bcn.2021.910.3
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author Mirfazeli, Fatemeh Sadat
Mohebi, Fatemeh
Jahanbakhshi, Amin
Aryani, Omid
Almasi-Dooghaee, Mostafa
author_facet Mirfazeli, Fatemeh Sadat
Mohebi, Fatemeh
Jahanbakhshi, Amin
Aryani, Omid
Almasi-Dooghaee, Mostafa
author_sort Mirfazeli, Fatemeh Sadat
collection PubMed
description Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS.
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spelling pubmed-102622892023-06-15 Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior Mirfazeli, Fatemeh Sadat Mohebi, Fatemeh Jahanbakhshi, Amin Aryani, Omid Almasi-Dooghaee, Mostafa Basic Clin Neurosci Case Report Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS. Tehran University of Medical Sciences 2022 2022-11-01 /pmc/articles/PMC10262289/ /pubmed/37323959 http://dx.doi.org/10.32598/bcn.2021.910.3 Text en Copyright© 2022 Iranian Neuroscience Society https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Case Report
Mirfazeli, Fatemeh Sadat
Mohebi, Fatemeh
Jahanbakhshi, Amin
Aryani, Omid
Almasi-Dooghaee, Mostafa
Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior
title Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior
title_full Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior
title_fullStr Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior
title_full_unstemmed Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior
title_short Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior
title_sort repetitive suicidal behaviors in a case with a new mutation of wolfram syndrome: a jump from the gene to the behavior
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262289/
https://www.ncbi.nlm.nih.gov/pubmed/37323959
http://dx.doi.org/10.32598/bcn.2021.910.3
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