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Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma

Ovarian cancer is driven by genetic alterations that necessitate protective DNA damage and replication stress responses through cell cycle control and genome maintenance. This creates specific vulnerabilities that may be exploited therapeutically. WEE1 kinase is a key cell cycle control kinase, and...

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Detalles Bibliográficos
Autores principales:	Benada, Jan, Bulanova, Daria, Azzoni, Violette, Petrosius, Valdemaras, Ghazanfar, Saba, Wennerberg, Krister, Sørensen, Claus Storgaard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262308/ https://www.ncbi.nlm.nih.gov/pubmed/37325550 http://dx.doi.org/10.1093/narcan/zcad029

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