Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells

Despite the success of cancer therapy, it has encountered a major obstacle due to the complicated nature of cancer, namely resistance. The recurrence and metastasis of cancer occur when anti-cancer therapeutic agents fail to eradicate all cancer cells. Cancer therapy aims to find the best agent that...

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Autores principales: Hosseinzadeh, Aysooda, Poursoleiman, Faezeh, Biregani, Akram Naghdipour, Esmailzadeh, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262367/
https://www.ncbi.nlm.nih.gov/pubmed/37308913
http://dx.doi.org/10.1186/s12935-023-02960-4
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author Hosseinzadeh, Aysooda
Poursoleiman, Faezeh
Biregani, Akram Naghdipour
Esmailzadeh, Ahmad
author_facet Hosseinzadeh, Aysooda
Poursoleiman, Faezeh
Biregani, Akram Naghdipour
Esmailzadeh, Ahmad
author_sort Hosseinzadeh, Aysooda
collection PubMed
description Despite the success of cancer therapy, it has encountered a major obstacle due to the complicated nature of cancer, namely resistance. The recurrence and metastasis of cancer occur when anti-cancer therapeutic agents fail to eradicate all cancer cells. Cancer therapy aims to find the best agent that targets all cancer cells, including those sensitive or resistant to treatment. Flavonoids, natural products from our diet, show anti-cancer effects in different studies. They can inhibit metastasis and the recurrence of cancers. This review discusses metastasis, autophagy, anoikis in cancer cells, and their dynamic relationship. We present evidence that flavonoids can block metastasis and induce cell death in cancer cells. Our research suggests that flavonoids can serve as potential therapeutic agents in cancer therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-023-02960-4.
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spelling pubmed-102623672023-06-15 Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells Hosseinzadeh, Aysooda Poursoleiman, Faezeh Biregani, Akram Naghdipour Esmailzadeh, Ahmad Cancer Cell Int Review Despite the success of cancer therapy, it has encountered a major obstacle due to the complicated nature of cancer, namely resistance. The recurrence and metastasis of cancer occur when anti-cancer therapeutic agents fail to eradicate all cancer cells. Cancer therapy aims to find the best agent that targets all cancer cells, including those sensitive or resistant to treatment. Flavonoids, natural products from our diet, show anti-cancer effects in different studies. They can inhibit metastasis and the recurrence of cancers. This review discusses metastasis, autophagy, anoikis in cancer cells, and their dynamic relationship. We present evidence that flavonoids can block metastasis and induce cell death in cancer cells. Our research suggests that flavonoids can serve as potential therapeutic agents in cancer therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-023-02960-4. BioMed Central 2023-06-12 /pmc/articles/PMC10262367/ /pubmed/37308913 http://dx.doi.org/10.1186/s12935-023-02960-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Hosseinzadeh, Aysooda
Poursoleiman, Faezeh
Biregani, Akram Naghdipour
Esmailzadeh, Ahmad
Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells
title Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells
title_full Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells
title_fullStr Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells
title_full_unstemmed Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells
title_short Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells
title_sort flavonoids target different molecules of autophagic and metastatic pathways in cancer cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262367/
https://www.ncbi.nlm.nih.gov/pubmed/37308913
http://dx.doi.org/10.1186/s12935-023-02960-4
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AT esmailzadehahmad flavonoidstargetdifferentmoleculesofautophagicandmetastaticpathwaysincancercells

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