SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair

BACKGROUND: Cisplatin is commonly used to treat cervical cancer while drug resistance limits its effectiveness. There is an urgent need to identify strategies that increase cisplatin sensitivity and improve the outcomes of chemotherapy. RESULTS: We performed whole exome sequencing (WES) of 156 cervi...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Cao, Chen, Tan, Xiangyu, Liao, Xueyao, Du, Xiaofang, Wang, Xueqian, Liu, Ting, Gong, Danni, Hu, Zheng, Tian, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262521/
https://www.ncbi.nlm.nih.gov/pubmed/37308924
http://dx.doi.org/10.1186/s13578-023-01054-y

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