Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models

BACKGROUND: Lysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson’s disease (PD). Various molecular, clinical and genetic studies have highlighted a central role of lysosomal pathways and proteins in the pathogenesis of PD. Within PD pathology the syna...

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Detalles Bibliográficos
Autores principales: Drobny, Alice, Boros, Fanni Annamária, Balta, Denise, Prieto Huarcaya, Susy, Caylioglu, Deniz, Qazi, Niyeti, Vandrey, Julia, Schneider, Yanni, Dobert, Jan Philipp, Pitcairn, Caleb, Mazzulli, Joseph Robert, Zunke, Friederike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262594/
https://www.ncbi.nlm.nih.gov/pubmed/37312133
http://dx.doi.org/10.1186/s40035-023-00363-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262594/
https://www.ncbi.nlm.nih.gov/pubmed/37312133
http://dx.doi.org/10.1186/s40035-023-00363-z

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