Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy

Extracellular pathogens utilize secreted virulence factors to regulate host cell function. Recently we characterized the molecular mechanism behind host macroautophagy/autophagy regulation by the Vibrio cholerae toxin MakA. Cholesterol binding at the plasma membrane induces MakA endocytosis and pH-d...

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Detalles Bibliográficos
Autores principales: Corkery, Dale P., Wu, Yao-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262753/
https://www.ncbi.nlm.nih.gov/pubmed/36409136
http://dx.doi.org/10.1080/15548627.2022.2146893
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author Corkery, Dale P.
Wu, Yao-Wen
author_facet Corkery, Dale P.
Wu, Yao-Wen
author_sort Corkery, Dale P.
collection PubMed
description Extracellular pathogens utilize secreted virulence factors to regulate host cell function. Recently we characterized the molecular mechanism behind host macroautophagy/autophagy regulation by the Vibrio cholerae toxin MakA. Cholesterol binding at the plasma membrane induces MakA endocytosis and pH-dependent pore assembly. Membrane perforation of late endosomal membranes induces cellular membrane repair pathways and V-ATPase-dependent unconventional LC3 lipidation on damaged membranes.
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spelling pubmed-102627532023-06-15 Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy Corkery, Dale P. Wu, Yao-Wen Autophagy Autophagic Punctum Extracellular pathogens utilize secreted virulence factors to regulate host cell function. Recently we characterized the molecular mechanism behind host macroautophagy/autophagy regulation by the Vibrio cholerae toxin MakA. Cholesterol binding at the plasma membrane induces MakA endocytosis and pH-dependent pore assembly. Membrane perforation of late endosomal membranes induces cellular membrane repair pathways and V-ATPase-dependent unconventional LC3 lipidation on damaged membranes. Taylor & Francis 2022-11-21 /pmc/articles/PMC10262753/ /pubmed/36409136 http://dx.doi.org/10.1080/15548627.2022.2146893 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Autophagic Punctum
Corkery, Dale P.
Wu, Yao-Wen
Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy
title Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy
title_full Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy
title_fullStr Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy
title_full_unstemmed Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy
title_short Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy
title_sort eating while intoxicated: characterizing the molecular mechanism behind v. cholerae toxin maka-regulated autophagy
topic Autophagic Punctum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262753/
https://www.ncbi.nlm.nih.gov/pubmed/36409136
http://dx.doi.org/10.1080/15548627.2022.2146893
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