Cargando…

Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction

Cognitive impairment caused by systemic chemotherapy is a critical question that perplexes the effective implementation of clinical treatment, but related molecular events are poorly understood. Herein, we show that bortezomib exposure leads to microglia activation and cognitive impairment, this occ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Yaping, Chen, Xiang, Liu, Xiuxiu, Shi, Yi, Wei, Zhaocong, Feng, Lili, Jiang, Quan, Ye, Weifeng, Sasaki, Takuya, Fukunaga, Kohji, Ji, Yong, Han, Feng, Lu, Ying-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262803/ https://www.ncbi.nlm.nih.gov/pubmed/36588318 http://dx.doi.org/10.1080/15548627.2022.2162244

Ejemplares similares

Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction
por: Luo, Li, et al.
Publicado: (2022)

TFEB insufficiency promotes cardiac hypertrophy by blocking autophagic degradation of GATA4
por: Song, Rui, et al.
Publicado: (2021)

TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
por: Wang, Baiping, et al.
Publicado: (2023)

Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux
por: Zhang, Shaoyi, et al.
Publicado: (2019)

Cyclosporine A blocks autophagic flux in tubular epithelial cells by impairing TFEB‐mediated lysosomal function
por: Li, Zhi‐hang, et al.
Publicado: (2021)

Endothelial peroxynitrite causes disturbance of neuronal oscillations by targeting caspase-1 in the arcuate nucleus
por: Sun, Meiling, et al.
Publicado: (2021)

Melatonin Restores Autophagic Flux by Activating the Sirt3/TFEB Signaling Pathway to Attenuate Doxorubicin-Induced Cardiomyopathy
por: Ma, Yanyan, et al.
Publicado: (2023)

Author Correction: Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux
por: Zhang, Shaoyi, et al.
Publicado: (2019)

Alcohol-Induced Pancreatitis: A Critical Role for TFEB in Maintaining Lysosomal Biogenesis and Autophagic Clearance
por: Cooley, Michelle M., et al.
Publicado: (2020)

Interleukin-4 affects microglial autophagic flux
por: Tang, Run-Hong, et al.
Publicado: (2019)

Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR
por: Ye, Bin, et al.
Publicado: (2019)

Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors
por: Kim, Sunhyo, et al.
Publicado: (2016)

Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis
por: Duan, Junchao, et al.
Publicado: (2014)

Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow
por: Liu, Yulan, et al.
Publicado: (2022)

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling
por: Ugolino, Janet, et al.
Publicado: (2016)

Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease
por: Zhou, Xiao-Gang, et al.
Publicado: (2022)

TFEB controls vascular development by regulating the proliferation of endothelial cells
por: Doronzo, Gabriella, et al.
Publicado: (2018)

APOL1 variant-expressing endothelial cells exhibit autophagic dysfunction and mitochondrial stress
por: Blazer, Ashira, et al.
Publicado: (2022)

Dihydromyricetin induced lncRNA MALAT1-TFEB-dependent autophagic cell death in cutaneous squamous cell carcinoma
por: Tan, Miduo, et al.
Publicado: (2019)

TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation
por: Cheng, Dan, et al.
Publicado: (2019)

MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer’s Disease
por: Chun, Yoon Sun, et al.
Publicado: (2022)

A splicing variant of TFEB negatively regulates the TFEB-autophagy pathway
por: Park, Jee-Yun, et al.
Publicado: (2021)

Role of hypoxia-inducible factor-1α in autophagic cell death in microglial cells induced by hypoxia
por: Wang, Xintao, et al.
Publicado: (2017)

TFEB controls integrin-mediated endothelial cell adhesion by the regulation of cholesterol metabolism
por: Ariano, Camilla, et al.
Publicado: (2022)

Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury
por: Zhu, Lingling, et al.
Publicado: (2020)

Upregulation of CFTR Protects against Palmitate-Induced Endothelial Dysfunction by Enhancing Autophagic Flux
por: Chen, Hongqi, et al.
Publicado: (2020)

Possible Neuropathology of Sleep Disturbance Linking to Alzheimer’s Disease: Astrocytic and Microglial Roles
por: Xiao, Shu-Yun, et al.
Publicado: (2022)

Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
por: Miyazaki, Masaya, et al.
Publicado: (2021)

Curcumin targets the TFEB-lysosome pathway for induction of autophagy
por: Zhang, Jianbin, et al.
Publicado: (2016)

Autophagic/lysosomal dysfunction in Alzheimer’s disease
por: Orr, Miranda E, et al.
Publicado: (2013)

Acute HCV/HIV Coinfection Is Associated with Cognitive Dysfunction and Cerebral Metabolite Disturbance, but Not Increased Microglial Cell Activation
por: Garvey, Lucy J., et al.
Publicado: (2012)

TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS
por: Cunningham, Kathleen M, et al.
Publicado: (2020)

TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer’s disease via TFEB/TFE3 activation
por: Lin, Wenjia, et al.
Publicado: (2023)

P1590: THE IFI27/TFEB PATHWAY MEDIATES THE IMPAIRED AUTOPHAGIC DEGRADATION OF ITP BONE MARROW MACROPHAGES, RESULTING IN IMPAIRED MEGAKARYOCYTE MATURATION IN ITP
por: Wu, Jin, et al.
Publicado: (2023)

PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury
por: Yuan, Longhui, et al.
Publicado: (2021)

Docetaxel enhances lysosomal function through TFEB activation
por: Zhang, Jianbin, et al.
Publicado: (2018)

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease
por: Kinghorn, Kerri J., et al.
Publicado: (2017)

Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway
por: Fu, Zhiling, et al.
Publicado: (2020)

Surviving starvation simply without TFEB
por: Soukas, Alexander A., et al.
Publicado: (2019)

TFEB Biology and Agonists at a Glance
por: Chen, Mingyue, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2c4vv163qabjkah42ftrelcool