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Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8(+) T cells

The autoimmune pathogenesis of type 1 diabetes (T1D) involves cellular infiltration from innate and adaptive immune subsets into the islets of Langerhans within the pancreas; however, the direct cytotoxic killing of insulin-producing β-cells is thought to be mediated primarily by antigen-specific CD...

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Detalles Bibliográficos
Autores principales:	Peters, Leeana D., Yeh, Wen-I, Arnoletti, Juan M., Brown, Matthew E., Posgai, Amanda L., Mathews, Clayton E., Brusko, Todd M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262917/ https://www.ncbi.nlm.nih.gov/pubmed/37325626 http://dx.doi.org/10.3389/fimmu.2023.1142648

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