Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Resistance to immune checkpoint blockade remains challenging in patients with non–small cell lung cancer (NSCLC). Tumor-infiltrating leukocyte (TIL) quantity, composition, and activation status profoundly influence responsiveness to cancer immunotherapy. This study examined the immune landscape in t...

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Detalles Bibliográficos
Autores principales: Aoki, Kazunori, Nishito, Yukari, Motoi, Noriko, Arai, Yasuhito, Hiraoka, Nobuyoshi, Shibata, Tatsuhiro, Sonobe, Yukiko, Kayukawa, Yoko, Hashimoto, Eri, Takahashi, Mina, Fujii, Etsuko, Nishizawa, Takashi, Fukuda, Hironori, Ohashi, Kana, Arai, Kosuke, Mizoguchi, Yukihiro, Yoshida, Yukihiro, Watanabe, Shun-ichi, Yamashita, Makiko, Kitano, Shigehisa, Sakamoto, Hiromi, Nagata, Yuki, Mitsumori, Risa, Ozaki, Kouichi, Niida, Shumpei, Kanai, Yae, Hirayama, Akiyoshi, Soga, Tomoyoshi, Maruyama, Toru, Tsukada, Keisuke, Yabuki, Nami, Shimada, Mei, Kitazawa, Takehisa, Natori, Osamu, Sawada, Noriaki, Kato, Atsuhiko, Yoshida, Teruhiko, Yasuda, Kazuki, Mizuno, Hideaki, Tsunoda, Hiroyuki, Ochiai, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263066/
https://www.ncbi.nlm.nih.gov/pubmed/37377611
http://dx.doi.org/10.1158/2767-9764.CRC-22-0415

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