Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates

Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also display hyper-activity when tested in iron-limited media against A. baumannii, K. pneumoniae, and E. coli. MICs were determined against represent...

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Autores principales: Lu, Peggy, Alletto, Francesco, Lee, Bosul, Burk, Elizabeth, Martinez, Jasmine, Prati, Fabio, Caselli, Emilia, Spellberg, Brad, Luna, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263351/
https://www.ncbi.nlm.nih.gov/pubmed/37310985
http://dx.doi.org/10.1371/journal.pone.0287102
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author Lu, Peggy
Alletto, Francesco
Lee, Bosul
Burk, Elizabeth
Martinez, Jasmine
Prati, Fabio
Caselli, Emilia
Spellberg, Brad
Luna, Brian
author_facet Lu, Peggy
Alletto, Francesco
Lee, Bosul
Burk, Elizabeth
Martinez, Jasmine
Prati, Fabio
Caselli, Emilia
Spellberg, Brad
Luna, Brian
author_sort Lu, Peggy
collection PubMed
description Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also display hyper-activity when tested in iron-limited media against A. baumannii, K. pneumoniae, and E. coli. MICs were determined against representative clinical isolates using the iron-limited media RPMI-1640. Only rifabutin was hyperactive against A. baumannii.
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spelling pubmed-102633512023-06-15 Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates Lu, Peggy Alletto, Francesco Lee, Bosul Burk, Elizabeth Martinez, Jasmine Prati, Fabio Caselli, Emilia Spellberg, Brad Luna, Brian PLoS One Research Article Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also display hyper-activity when tested in iron-limited media against A. baumannii, K. pneumoniae, and E. coli. MICs were determined against representative clinical isolates using the iron-limited media RPMI-1640. Only rifabutin was hyperactive against A. baumannii. Public Library of Science 2023-06-13 /pmc/articles/PMC10263351/ /pubmed/37310985 http://dx.doi.org/10.1371/journal.pone.0287102 Text en © 2023 Lu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lu, Peggy
Alletto, Francesco
Lee, Bosul
Burk, Elizabeth
Martinez, Jasmine
Prati, Fabio
Caselli, Emilia
Spellberg, Brad
Luna, Brian
Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates
title Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates
title_full Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates
title_fullStr Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates
title_full_unstemmed Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates
title_short Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates
title_sort defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against acinetobacter baumannii, escherichia coli, and klebsiella pneumoniae clinical isolates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263351/
https://www.ncbi.nlm.nih.gov/pubmed/37310985
http://dx.doi.org/10.1371/journal.pone.0287102
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