Cargando…
Natural history of long-COVID in a nationwide, population cohort study
Previous studies on the natural history of long-COVID have been few and selective. Without comparison groups, disease progression cannot be differentiated from symptoms originating from other causes. The Long-COVID in Scotland Study (Long-CISS) is a Scotland-wide, general population cohort of adults...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263377/ https://www.ncbi.nlm.nih.gov/pubmed/37311808 http://dx.doi.org/10.1038/s41467-023-39193-y |
_version_ | 1785058228047970304 |
---|---|
author | Hastie, Claire E. Lowe, David J. McAuley, Andrew Mills, Nicholas L. Winter, Andrew J. Black, Corri Scott, Janet T. O’Donnell, Catherine A. Blane, David N. Browne, Susan Ibbotson, Tracy R. Pell, Jill P. |
author_facet | Hastie, Claire E. Lowe, David J. McAuley, Andrew Mills, Nicholas L. Winter, Andrew J. Black, Corri Scott, Janet T. O’Donnell, Catherine A. Blane, David N. Browne, Susan Ibbotson, Tracy R. Pell, Jill P. |
author_sort | Hastie, Claire E. |
collection | PubMed |
description | Previous studies on the natural history of long-COVID have been few and selective. Without comparison groups, disease progression cannot be differentiated from symptoms originating from other causes. The Long-COVID in Scotland Study (Long-CISS) is a Scotland-wide, general population cohort of adults who had laboratory-confirmed SARS-CoV-2 infection matched to PCR-negative adults. Serial, self-completed, online questionnaires collected information on pre-existing health conditions and current health six, 12 and 18 months after index test. Of those with previous symptomatic infection, 35% reported persistent incomplete/no recovery, 12% improvement and 12% deterioration. At six and 12 months, one or more symptom was reported by 71.5% and 70.7% respectively of those previously infected, compared with 53.5% and 56.5% of those never infected. Altered taste, smell and confusion improved over time compared to the never infected group and adjusted for confounders. Conversely, late onset dry and productive cough, and hearing problems were more likely following SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-10263377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102633772023-06-14 Natural history of long-COVID in a nationwide, population cohort study Hastie, Claire E. Lowe, David J. McAuley, Andrew Mills, Nicholas L. Winter, Andrew J. Black, Corri Scott, Janet T. O’Donnell, Catherine A. Blane, David N. Browne, Susan Ibbotson, Tracy R. Pell, Jill P. Nat Commun Article Previous studies on the natural history of long-COVID have been few and selective. Without comparison groups, disease progression cannot be differentiated from symptoms originating from other causes. The Long-COVID in Scotland Study (Long-CISS) is a Scotland-wide, general population cohort of adults who had laboratory-confirmed SARS-CoV-2 infection matched to PCR-negative adults. Serial, self-completed, online questionnaires collected information on pre-existing health conditions and current health six, 12 and 18 months after index test. Of those with previous symptomatic infection, 35% reported persistent incomplete/no recovery, 12% improvement and 12% deterioration. At six and 12 months, one or more symptom was reported by 71.5% and 70.7% respectively of those previously infected, compared with 53.5% and 56.5% of those never infected. Altered taste, smell and confusion improved over time compared to the never infected group and adjusted for confounders. Conversely, late onset dry and productive cough, and hearing problems were more likely following SARS-CoV-2 infection. Nature Publishing Group UK 2023-06-13 /pmc/articles/PMC10263377/ /pubmed/37311808 http://dx.doi.org/10.1038/s41467-023-39193-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hastie, Claire E. Lowe, David J. McAuley, Andrew Mills, Nicholas L. Winter, Andrew J. Black, Corri Scott, Janet T. O’Donnell, Catherine A. Blane, David N. Browne, Susan Ibbotson, Tracy R. Pell, Jill P. Natural history of long-COVID in a nationwide, population cohort study |
title | Natural history of long-COVID in a nationwide, population cohort study |
title_full | Natural history of long-COVID in a nationwide, population cohort study |
title_fullStr | Natural history of long-COVID in a nationwide, population cohort study |
title_full_unstemmed | Natural history of long-COVID in a nationwide, population cohort study |
title_short | Natural history of long-COVID in a nationwide, population cohort study |
title_sort | natural history of long-covid in a nationwide, population cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263377/ https://www.ncbi.nlm.nih.gov/pubmed/37311808 http://dx.doi.org/10.1038/s41467-023-39193-y |
work_keys_str_mv | AT hastieclairee naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT lowedavidj naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT mcauleyandrew naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT millsnicholasl naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT winterandrewj naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT blackcorri naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT scottjanett naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT odonnellcatherinea naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT blanedavidn naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT brownesusan naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT ibbotsontracyr naturalhistoryoflongcovidinanationwidepopulationcohortstudy AT pelljillp naturalhistoryoflongcovidinanationwidepopulationcohortstudy |