Cargando…

Natural history of long-COVID in a nationwide, population cohort study

Previous studies on the natural history of long-COVID have been few and selective. Without comparison groups, disease progression cannot be differentiated from symptoms originating from other causes. The Long-COVID in Scotland Study (Long-CISS) is a Scotland-wide, general population cohort of adults...

Descripción completa

Detalles Bibliográficos
Autores principales: Hastie, Claire E., Lowe, David J., McAuley, Andrew, Mills, Nicholas L., Winter, Andrew J., Black, Corri, Scott, Janet T., O’Donnell, Catherine A., Blane, David N., Browne, Susan, Ibbotson, Tracy R., Pell, Jill P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263377/
https://www.ncbi.nlm.nih.gov/pubmed/37311808
http://dx.doi.org/10.1038/s41467-023-39193-y
_version_ 1785058228047970304
author Hastie, Claire E.
Lowe, David J.
McAuley, Andrew
Mills, Nicholas L.
Winter, Andrew J.
Black, Corri
Scott, Janet T.
O’Donnell, Catherine A.
Blane, David N.
Browne, Susan
Ibbotson, Tracy R.
Pell, Jill P.
author_facet Hastie, Claire E.
Lowe, David J.
McAuley, Andrew
Mills, Nicholas L.
Winter, Andrew J.
Black, Corri
Scott, Janet T.
O’Donnell, Catherine A.
Blane, David N.
Browne, Susan
Ibbotson, Tracy R.
Pell, Jill P.
author_sort Hastie, Claire E.
collection PubMed
description Previous studies on the natural history of long-COVID have been few and selective. Without comparison groups, disease progression cannot be differentiated from symptoms originating from other causes. The Long-COVID in Scotland Study (Long-CISS) is a Scotland-wide, general population cohort of adults who had laboratory-confirmed SARS-CoV-2 infection matched to PCR-negative adults. Serial, self-completed, online questionnaires collected information on pre-existing health conditions and current health six, 12 and 18 months after index test. Of those with previous symptomatic infection, 35% reported persistent incomplete/no recovery, 12% improvement and 12% deterioration. At six and 12 months, one or more symptom was reported by 71.5% and 70.7% respectively of those previously infected, compared with 53.5% and 56.5% of those never infected. Altered taste, smell and confusion improved over time compared to the never infected group and adjusted for confounders. Conversely, late onset dry and productive cough, and hearing problems were more likely following SARS-CoV-2 infection.
format Online
Article
Text
id pubmed-10263377
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-102633772023-06-14 Natural history of long-COVID in a nationwide, population cohort study Hastie, Claire E. Lowe, David J. McAuley, Andrew Mills, Nicholas L. Winter, Andrew J. Black, Corri Scott, Janet T. O’Donnell, Catherine A. Blane, David N. Browne, Susan Ibbotson, Tracy R. Pell, Jill P. Nat Commun Article Previous studies on the natural history of long-COVID have been few and selective. Without comparison groups, disease progression cannot be differentiated from symptoms originating from other causes. The Long-COVID in Scotland Study (Long-CISS) is a Scotland-wide, general population cohort of adults who had laboratory-confirmed SARS-CoV-2 infection matched to PCR-negative adults. Serial, self-completed, online questionnaires collected information on pre-existing health conditions and current health six, 12 and 18 months after index test. Of those with previous symptomatic infection, 35% reported persistent incomplete/no recovery, 12% improvement and 12% deterioration. At six and 12 months, one or more symptom was reported by 71.5% and 70.7% respectively of those previously infected, compared with 53.5% and 56.5% of those never infected. Altered taste, smell and confusion improved over time compared to the never infected group and adjusted for confounders. Conversely, late onset dry and productive cough, and hearing problems were more likely following SARS-CoV-2 infection. Nature Publishing Group UK 2023-06-13 /pmc/articles/PMC10263377/ /pubmed/37311808 http://dx.doi.org/10.1038/s41467-023-39193-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hastie, Claire E.
Lowe, David J.
McAuley, Andrew
Mills, Nicholas L.
Winter, Andrew J.
Black, Corri
Scott, Janet T.
O’Donnell, Catherine A.
Blane, David N.
Browne, Susan
Ibbotson, Tracy R.
Pell, Jill P.
Natural history of long-COVID in a nationwide, population cohort study
title Natural history of long-COVID in a nationwide, population cohort study
title_full Natural history of long-COVID in a nationwide, population cohort study
title_fullStr Natural history of long-COVID in a nationwide, population cohort study
title_full_unstemmed Natural history of long-COVID in a nationwide, population cohort study
title_short Natural history of long-COVID in a nationwide, population cohort study
title_sort natural history of long-covid in a nationwide, population cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263377/
https://www.ncbi.nlm.nih.gov/pubmed/37311808
http://dx.doi.org/10.1038/s41467-023-39193-y
work_keys_str_mv AT hastieclairee naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT lowedavidj naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT mcauleyandrew naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT millsnicholasl naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT winterandrewj naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT blackcorri naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT scottjanett naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT odonnellcatherinea naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT blanedavidn naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT brownesusan naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT ibbotsontracyr naturalhistoryoflongcovidinanationwidepopulationcohortstudy
AT pelljillp naturalhistoryoflongcovidinanationwidepopulationcohortstudy