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INVERSE RELATIONSHIP BETWEEN PLASMA PROTEINS AND SATISFACTORY SURGICAL WOUNDS OUTCOME
OBJECTIVE: This study investigated the factors associated with satisfactory early postoperative wound conditions. METHOD: A prospective study was conducted with patients (n=179) submitted to osteosynthesis in general, in a hospital orthopedics service. In the preoperative period, patients underwent...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
ATHA EDITORA
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263440/ https://www.ncbi.nlm.nih.gov/pubmed/37323150 http://dx.doi.org/10.1590/1413-785220233102e263313 |
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author | JAQUETO, PEDRO AUGUSTO SABBAG, IASMIN CHAGAS SILVA, LEONARDO PEDRÃO DA NUNES, LUCCAS FRANCO BETTENCOURT MATTOS, CARLOS AUGUSTO DE LEANDRO-MERHI, VÂNIA APARECIDA |
author_facet | JAQUETO, PEDRO AUGUSTO SABBAG, IASMIN CHAGAS SILVA, LEONARDO PEDRÃO DA NUNES, LUCCAS FRANCO BETTENCOURT MATTOS, CARLOS AUGUSTO DE LEANDRO-MERHI, VÂNIA APARECIDA |
author_sort | JAQUETO, PEDRO AUGUSTO |
collection | PubMed |
description | OBJECTIVE: This study investigated the factors associated with satisfactory early postoperative wound conditions. METHOD: A prospective study was conducted with patients (n=179) submitted to osteosynthesis in general, in a hospital orthopedics service. In the preoperative period, patients underwent laboratory exams and the surgical indications were based on the type of fracture and the patient’s clinical conditions. In the postoperative period, patients were evaluated based on the presence of complications and considering their surgical wounds. Chi-square, Fisher, Mann-Whitney, and Kruskal-Wallis tests were used in the analysis. To identify the factors associated with wound condition, univariate and multiple logistic regression analysis was used. RESULTS: In the univariate analysis, each transferring unit reduction increased the chance of satisfactory outcome by 1.1% (p=0.0306; OR= 0.989 (1.011); 95%CI= 0.978;0.999; 1.001;1.023). The presence of SAH increased 2.7 fold the chance of satisfactory outcome (p=0.0424; OR= 2,667; 95%CI= 1,034;6,877). Hip fracture increased 2.6 fold the chance of satisfactory outcome (p=0.0272; OR=2.593; IC95%=1.113; 6.039). And the absence of a compound fracture increased 5.5 fold the chance of satisfactory wound outcome (p=0.0004; OR=5,493; 95%CI=2,132;14,149). In the multiple analysis, patients with non compound fractures were 9.7 times more likely to experience a satisfactory outcome when compared to patients with compound fractures (p=0.0014; OR=9,687; 95%CI= 2,399; 39,125). CONCLUSION: There was an inverse relationship between plasma proteins levels and satisfactory surgical wounds outcome. Only exposure remained associated with wound conditions. Level Of Evidence: II, Prospective Study. |
format | Online Article Text |
id | pubmed-10263440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | ATHA EDITORA |
record_format | MEDLINE/PubMed |
spelling | pubmed-102634402023-06-15 INVERSE RELATIONSHIP BETWEEN PLASMA PROTEINS AND SATISFACTORY SURGICAL WOUNDS OUTCOME JAQUETO, PEDRO AUGUSTO SABBAG, IASMIN CHAGAS SILVA, LEONARDO PEDRÃO DA NUNES, LUCCAS FRANCO BETTENCOURT MATTOS, CARLOS AUGUSTO DE LEANDRO-MERHI, VÂNIA APARECIDA Acta Ortop Bras Original Article OBJECTIVE: This study investigated the factors associated with satisfactory early postoperative wound conditions. METHOD: A prospective study was conducted with patients (n=179) submitted to osteosynthesis in general, in a hospital orthopedics service. In the preoperative period, patients underwent laboratory exams and the surgical indications were based on the type of fracture and the patient’s clinical conditions. In the postoperative period, patients were evaluated based on the presence of complications and considering their surgical wounds. Chi-square, Fisher, Mann-Whitney, and Kruskal-Wallis tests were used in the analysis. To identify the factors associated with wound condition, univariate and multiple logistic regression analysis was used. RESULTS: In the univariate analysis, each transferring unit reduction increased the chance of satisfactory outcome by 1.1% (p=0.0306; OR= 0.989 (1.011); 95%CI= 0.978;0.999; 1.001;1.023). The presence of SAH increased 2.7 fold the chance of satisfactory outcome (p=0.0424; OR= 2,667; 95%CI= 1,034;6,877). Hip fracture increased 2.6 fold the chance of satisfactory outcome (p=0.0272; OR=2.593; IC95%=1.113; 6.039). And the absence of a compound fracture increased 5.5 fold the chance of satisfactory wound outcome (p=0.0004; OR=5,493; 95%CI=2,132;14,149). In the multiple analysis, patients with non compound fractures were 9.7 times more likely to experience a satisfactory outcome when compared to patients with compound fractures (p=0.0014; OR=9,687; 95%CI= 2,399; 39,125). CONCLUSION: There was an inverse relationship between plasma proteins levels and satisfactory surgical wounds outcome. Only exposure remained associated with wound conditions. Level Of Evidence: II, Prospective Study. ATHA EDITORA 2023-06-09 /pmc/articles/PMC10263440/ /pubmed/37323150 http://dx.doi.org/10.1590/1413-785220233102e263313 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article JAQUETO, PEDRO AUGUSTO SABBAG, IASMIN CHAGAS SILVA, LEONARDO PEDRÃO DA NUNES, LUCCAS FRANCO BETTENCOURT MATTOS, CARLOS AUGUSTO DE LEANDRO-MERHI, VÂNIA APARECIDA INVERSE RELATIONSHIP BETWEEN PLASMA PROTEINS AND SATISFACTORY SURGICAL WOUNDS OUTCOME |
title | INVERSE RELATIONSHIP BETWEEN PLASMA PROTEINS AND SATISFACTORY SURGICAL WOUNDS OUTCOME |
title_full | INVERSE RELATIONSHIP BETWEEN PLASMA PROTEINS AND SATISFACTORY SURGICAL WOUNDS OUTCOME |
title_fullStr | INVERSE RELATIONSHIP BETWEEN PLASMA PROTEINS AND SATISFACTORY SURGICAL WOUNDS OUTCOME |
title_full_unstemmed | INVERSE RELATIONSHIP BETWEEN PLASMA PROTEINS AND SATISFACTORY SURGICAL WOUNDS OUTCOME |
title_short | INVERSE RELATIONSHIP BETWEEN PLASMA PROTEINS AND SATISFACTORY SURGICAL WOUNDS OUTCOME |
title_sort | inverse relationship between plasma proteins and satisfactory surgical wounds outcome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263440/ https://www.ncbi.nlm.nih.gov/pubmed/37323150 http://dx.doi.org/10.1590/1413-785220233102e263313 |
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