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Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis
BACKGROUND: Actinic keratosis (AK), or solar keratosis, is a precancerous condition of the skin, mainly caused by excessive and chronic exposure to ultraviolet radiation. Pigmented AK (pAK) is a rare variant of AK. Photodynamic therapy (PDT) is widely used to treat the classical variant of AK, but v...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264342/ https://www.ncbi.nlm.nih.gov/pubmed/37162710 http://dx.doi.org/10.1007/s13555-023-00924-0 |
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author | Mazur, Ewelina Reich, Adam |
author_facet | Mazur, Ewelina Reich, Adam |
author_sort | Mazur, Ewelina |
collection | PubMed |
description | BACKGROUND: Actinic keratosis (AK), or solar keratosis, is a precancerous condition of the skin, mainly caused by excessive and chronic exposure to ultraviolet radiation. Pigmented AK (pAK) is a rare variant of AK. Photodynamic therapy (PDT) is widely used to treat the classical variant of AK, but very limited data are available on the use of PDT in patients with pAK. The objective of this study was to assess the usefulness of PDT in the treatment of pAK. METHODS: The study included 16 patients with 20 pAK lesions treated with PDT. All skin lesions were clinically and dermatoscopically assessed for typical features characteristic of pAK. Reflectance confocal microscopy (RCM) was also used to assess keratinocyte atypia, confirm pAK diagnosis, and rule out other disease entities. RESULTS: After three PDT sessions, the complete resolution of all clinical features of pAK was observed in 80% of the studied lesions. Dermatoscopically, 65% of the lesions achieved 100% response and no cellular atypia was seen in the follow-up RCM images of 85% of lesions. CONCLUSIONS: Photodynamic therapy is an effective treatment modality for pAK in fair-skinned individuals. |
format | Online Article Text |
id | pubmed-10264342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-102643422023-06-15 Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis Mazur, Ewelina Reich, Adam Dermatol Ther (Heidelb) Original Research BACKGROUND: Actinic keratosis (AK), or solar keratosis, is a precancerous condition of the skin, mainly caused by excessive and chronic exposure to ultraviolet radiation. Pigmented AK (pAK) is a rare variant of AK. Photodynamic therapy (PDT) is widely used to treat the classical variant of AK, but very limited data are available on the use of PDT in patients with pAK. The objective of this study was to assess the usefulness of PDT in the treatment of pAK. METHODS: The study included 16 patients with 20 pAK lesions treated with PDT. All skin lesions were clinically and dermatoscopically assessed for typical features characteristic of pAK. Reflectance confocal microscopy (RCM) was also used to assess keratinocyte atypia, confirm pAK diagnosis, and rule out other disease entities. RESULTS: After three PDT sessions, the complete resolution of all clinical features of pAK was observed in 80% of the studied lesions. Dermatoscopically, 65% of the lesions achieved 100% response and no cellular atypia was seen in the follow-up RCM images of 85% of lesions. CONCLUSIONS: Photodynamic therapy is an effective treatment modality for pAK in fair-skinned individuals. Springer Healthcare 2023-05-10 /pmc/articles/PMC10264342/ /pubmed/37162710 http://dx.doi.org/10.1007/s13555-023-00924-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Mazur, Ewelina Reich, Adam Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
title | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
title_full | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
title_fullStr | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
title_full_unstemmed | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
title_short | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
title_sort | photodynamic therapy is an effective treatment of facial pigmented actinic keratosis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264342/ https://www.ncbi.nlm.nih.gov/pubmed/37162710 http://dx.doi.org/10.1007/s13555-023-00924-0 |
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