Cargando…
Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation
Transcutaneous auricular vagus nerve stimulation (taVNS) shows excellent effects on relieving clinical symptoms in migraine patients. Nevertheless, the neurological mechanisms of taVNS for migraineurs remain unclear. In recent years, voxel-wise degree centrality (DC) and functional connectivity (FC)...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264378/ https://www.ncbi.nlm.nih.gov/pubmed/37311825 http://dx.doi.org/10.1038/s41598-023-36437-1 |
_version_ | 1785058310340214784 |
---|---|
author | Rao, Yuyang Liu, Wenting Zhu, Yunpeng Lin, Qiwen Kuang, Changyi Huang, Huiyuan Jiao, Bingqing Ma, Lijun Lin, Jiabao |
author_facet | Rao, Yuyang Liu, Wenting Zhu, Yunpeng Lin, Qiwen Kuang, Changyi Huang, Huiyuan Jiao, Bingqing Ma, Lijun Lin, Jiabao |
author_sort | Rao, Yuyang |
collection | PubMed |
description | Transcutaneous auricular vagus nerve stimulation (taVNS) shows excellent effects on relieving clinical symptoms in migraine patients. Nevertheless, the neurological mechanisms of taVNS for migraineurs remain unclear. In recent years, voxel-wise degree centrality (DC) and functional connectivity (FC) methods were extensively utilized for exploring alterations in patterns of FC in the resting-state brain. In the present study, thirty-five migraine patients without aura and thirty-eight healthy controls (HCs) were recruited for magnetic resonance imaging scans. Firstly, this study used voxel-wise DC analysis to explore brain regions where abnormalities were present in migraine patients. Secondly, for elucidating neurological mechanisms underlying taVNS in migraine, seed-based resting-state functional connectivity analysis was employed to the taVNS treatment group. Finally, correlation analysis was performed to explore the relationship between alterations in neurological mechanisms and clinical symptoms. Our findings indicated that migraineurs have lower DC values in the inferior temporal gyrus (ITG) and paracentral lobule than in healthy controls (HCs). In addition, migraineurs have higher DC values in the cerebellar lobule VIII and the fusiform gyrus than HCs. Moreover, after taVNS treatment (post-taVNS), patients displayed increased FC between the ITG with the inferior parietal lobule (IPL), orbitofrontal gyrus, angular gyrus, and posterior cingulate gyrus than before taVNS treatment (pre-taVNS). Besides, the post-taVNS patients showed decreased FC between the cerebellar lobule VIII with the supplementary motor area and postcentral gyrus compared with the pre-taVNS patients. The changed FC of ITG-IPL was significantly related to changes in headache intensity. Our study suggested that migraine patients without aura have altered brain connectivity patterns in several hub regions involving multisensory integration, pain perception, and cognitive function. More importantly, taVNS modulated the default mode network and the vestibular cortical network related to the dysfunctions in migraineurs. This paper provides a new perspective on the potential neurological mechanisms and therapeutic targets of taVNS for treating migraine. |
format | Online Article Text |
id | pubmed-10264378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102643782023-06-15 Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation Rao, Yuyang Liu, Wenting Zhu, Yunpeng Lin, Qiwen Kuang, Changyi Huang, Huiyuan Jiao, Bingqing Ma, Lijun Lin, Jiabao Sci Rep Article Transcutaneous auricular vagus nerve stimulation (taVNS) shows excellent effects on relieving clinical symptoms in migraine patients. Nevertheless, the neurological mechanisms of taVNS for migraineurs remain unclear. In recent years, voxel-wise degree centrality (DC) and functional connectivity (FC) methods were extensively utilized for exploring alterations in patterns of FC in the resting-state brain. In the present study, thirty-five migraine patients without aura and thirty-eight healthy controls (HCs) were recruited for magnetic resonance imaging scans. Firstly, this study used voxel-wise DC analysis to explore brain regions where abnormalities were present in migraine patients. Secondly, for elucidating neurological mechanisms underlying taVNS in migraine, seed-based resting-state functional connectivity analysis was employed to the taVNS treatment group. Finally, correlation analysis was performed to explore the relationship between alterations in neurological mechanisms and clinical symptoms. Our findings indicated that migraineurs have lower DC values in the inferior temporal gyrus (ITG) and paracentral lobule than in healthy controls (HCs). In addition, migraineurs have higher DC values in the cerebellar lobule VIII and the fusiform gyrus than HCs. Moreover, after taVNS treatment (post-taVNS), patients displayed increased FC between the ITG with the inferior parietal lobule (IPL), orbitofrontal gyrus, angular gyrus, and posterior cingulate gyrus than before taVNS treatment (pre-taVNS). Besides, the post-taVNS patients showed decreased FC between the cerebellar lobule VIII with the supplementary motor area and postcentral gyrus compared with the pre-taVNS patients. The changed FC of ITG-IPL was significantly related to changes in headache intensity. Our study suggested that migraine patients without aura have altered brain connectivity patterns in several hub regions involving multisensory integration, pain perception, and cognitive function. More importantly, taVNS modulated the default mode network and the vestibular cortical network related to the dysfunctions in migraineurs. This paper provides a new perspective on the potential neurological mechanisms and therapeutic targets of taVNS for treating migraine. Nature Publishing Group UK 2023-06-13 /pmc/articles/PMC10264378/ /pubmed/37311825 http://dx.doi.org/10.1038/s41598-023-36437-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Rao, Yuyang Liu, Wenting Zhu, Yunpeng Lin, Qiwen Kuang, Changyi Huang, Huiyuan Jiao, Bingqing Ma, Lijun Lin, Jiabao Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation |
title | Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation |
title_full | Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation |
title_fullStr | Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation |
title_full_unstemmed | Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation |
title_short | Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation |
title_sort | altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264378/ https://www.ncbi.nlm.nih.gov/pubmed/37311825 http://dx.doi.org/10.1038/s41598-023-36437-1 |
work_keys_str_mv | AT raoyuyang alteredfunctionalbrainnetworkpatternsinpatientswithmigrainewithoutauraaftertranscutaneousauricularvagusnervestimulation AT liuwenting alteredfunctionalbrainnetworkpatternsinpatientswithmigrainewithoutauraaftertranscutaneousauricularvagusnervestimulation AT zhuyunpeng alteredfunctionalbrainnetworkpatternsinpatientswithmigrainewithoutauraaftertranscutaneousauricularvagusnervestimulation AT linqiwen alteredfunctionalbrainnetworkpatternsinpatientswithmigrainewithoutauraaftertranscutaneousauricularvagusnervestimulation AT kuangchangyi alteredfunctionalbrainnetworkpatternsinpatientswithmigrainewithoutauraaftertranscutaneousauricularvagusnervestimulation AT huanghuiyuan alteredfunctionalbrainnetworkpatternsinpatientswithmigrainewithoutauraaftertranscutaneousauricularvagusnervestimulation AT jiaobingqing alteredfunctionalbrainnetworkpatternsinpatientswithmigrainewithoutauraaftertranscutaneousauricularvagusnervestimulation AT malijun alteredfunctionalbrainnetworkpatternsinpatientswithmigrainewithoutauraaftertranscutaneousauricularvagusnervestimulation AT linjiabao alteredfunctionalbrainnetworkpatternsinpatientswithmigrainewithoutauraaftertranscutaneousauricularvagusnervestimulation |