Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P

Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and SELENOP-mediated transport from the liver to e.g. the brain. In addition, the liver maintains copper homeostasis. Selenium and copper metabolism are inversely regulated, as increasing copper and decreasing selenium...

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Detalles Bibliográficos
Autores principales: Schwarz, Maria, Meyer, Caroline E., Löser, Alina, Lossow, Kristina, Hackler, Julian, Ott, Christiane, Jäger, Susanne, Mohr, Isabelle, Eklund, Ella A., Patel, Angana A. H., Gul, Nadia, Alvarez, Samantha, Altinonder, Ilayda, Wiel, Clotilde, Maares, Maria, Haase, Hajo, Härtlova, Anetta, Grune, Tilman, Schulze, Matthias B., Schwerdtle, Tanja, Merle, Uta, Zischka, Hans, Sayin, Volkan I., Schomburg, Lutz, Kipp, Anna P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264388/
https://www.ncbi.nlm.nih.gov/pubmed/37311819
http://dx.doi.org/10.1038/s41467-023-39245-3

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